The physiology of the vasculature in the central nervous system (CNS), which includes the
blood–brain barrier (BBB) and other factors, complicates the delivery of most drugs to the …

High intensity beams of ultrasound may be focused at depth within the body, thereby
producing selective damage within the focal volume, with no harm to overlying or …

The blood–brain barrier (BBB) prevents entry of most drugs into the brain and is a major
hurdle to the use of drugs for brain tumors and other central nervous system disorders. Work …

Acoustic emission was monitored during focused ultrasound exposures in conjunction with
an ultrasound contrast agent (Optison®) in order to determine if cavitation activity is …

In this study the threshold of thermally significant transient cavitation in vivo in dog's thigh
muscle was investigated as a function of frequency from 0.246 MHz to 1.68 MHz. Cavitation …

Time-resolved measurements of the temperature field in an agar-based tissue-mimicking
phantom insonated with a large aperture 1-MHz focused acoustic transducer are reported …

Focused ultrasound offers a method to disrupt the blood-brain barrier (BBB) noninvasively
and reversibly at targeted locations. The purpose of this study was to test the safety of this …

Methods were investigated to acoustically control the extent to which cavitation-mediated
tissue homogenization is responsible for lesion formation in vitro. These results may guide …

Advances in neuroscience have resulted in the development of new diagnostic and
therapeutic agents for potential use in the central nervous system (CNS). However, the …

The importance of nonlinear acoustic wave propagation and ultrasound-induced cavitation
in the acceleration of thermal lesion production by high intensity focused ultrasound was …