COVID-19 vaccine update: vaccine effectiveness, SARS-CoV-2 variants, boosters, adverse effects, and immune correlates of protection
Abstract Coronavirus Disease 2019 (COVID-19) has been the most severe public health
challenge in this century. Two years after its emergence, the rapid development and …
challenge in this century. Two years after its emergence, the rapid development and …
A detailed overview of SARS-CoV-2 omicron: its sub-variants, mutations and pathophysiology, clinical characteristics, immunological landscape, immune escape, and …
The COVID-19 pandemic has created significant concern for everyone. Recent data from
many worldwide reports suggest that most infections are caused by the Omicron variant and …
many worldwide reports suggest that most infections are caused by the Omicron variant and …
Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant
The Delta variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
outcompeted previously prevalent variants and become a dominant strain worldwide. We …
outcompeted previously prevalent variants and become a dominant strain worldwide. We …
Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape
Z Zhao, J Zhou, M Tian, M Huang, S Liu, Y Xie… - Nature …, 2022 - nature.com
Omicron SARS-CoV-2 is rapidly spreading worldwide. To delineate the impact of emerging
mutations on spike's properties, we performed systematic structural analyses on apo …
mutations on spike's properties, we performed systematic structural analyses on apo …
White-tailed deer (Odocoileus virginianus) may serve as a wildlife reservoir for nearly extinct SARS-CoV-2 variants of concern
The spillover of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from
humans to white-tailed deer (WTD) and its ability to transmit from deer to deer raised …
humans to white-tailed deer (WTD) and its ability to transmit from deer to deer raised …
SARS-CoV-2 variants of concern: spike protein mutational analysis and epitope for broad neutralization
D Mannar, JW Saville, Z Sun, X Zhu, MM Marti… - Nature …, 2022 - nature.com
Mutations in the spike glycoproteins of SARS-CoV-2 variants of concern have independently
been shown to enhance aspects of spike protein fitness. Here, we describe an antibody …
been shown to enhance aspects of spike protein fitness. Here, we describe an antibody …
Clinical grade ACE2 as a universal agent to block SARS‐CoV‐2 variants
The recent emergence of multiple SARS‐CoV‐2 variants has caused considerable concern
due to both reduced vaccine efficacy and escape from neutralizing antibody therapeutics. It …
due to both reduced vaccine efficacy and escape from neutralizing antibody therapeutics. It …
Structural dynamics in the evolution of SARS-CoV-2 spike glycoprotein
V Calvaresi, AG Wrobel, J Toporowska… - Nature …, 2023 - nature.com
SARS-CoV-2 spike glycoprotein mediates receptor binding and subsequent membrane
fusion. It exists in a range of conformations, including a closed state unable to bind the ACE2 …
fusion. It exists in a range of conformations, including a closed state unable to bind the ACE2 …
Conformational dynamics of the Beta and Kappa SARS-CoV-2 spike proteins and their complexes with ACE2 receptor revealed by cryo-EM
The emergence of SARS-CoV-2 Kappa and Beta variants with enhanced transmissibility
and resistance to neutralizing antibodies has created new challenges for the control of the …
and resistance to neutralizing antibodies has created new challenges for the control of the …
Binding of human ACE2 and RBD of omicron enhanced by unique interaction patterns among SARS‐CoV‐2 variants of concern
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the virus causing COVID‐
19, has continued to mutate and spread worldwide despite global vaccination efforts. In …
19, has continued to mutate and spread worldwide despite global vaccination efforts. In …