[HTML][HTML] The evolving role of investigative toxicology in the pharmaceutical industry

F Pognan, M Beilmann, H Boonen, A Czich… - Nature reviews drug …, 2023 - nature.com
For decades, preclinical toxicology was essentially a descriptive discipline in which
treatment-related effects were carefully reported and used as a basis to calculate safety …

The immunopathogenesis of narcolepsy type 1

RS Liblau, D Latorre, BR Kornum… - Nature Reviews …, 2024 - nature.com
Abstract Narcolepsy type 1 (NT1) is a chronic sleep disorder resulting from the loss of a
small population of hypothalamic neurons that produce wake-promoting hypocretin (HCRT; …

A comprehensive benchmarking with practical guidelines for cellular deconvolution of spatial transcriptomics

H Li, J Zhou, Z Li, S Chen, X Liao, B Zhang… - Nature …, 2023 - nature.com
Spatial transcriptomics technologies are used to profile transcriptomes while preserving
spatial information, which enables high-resolution characterization of transcriptional patterns …

Friend or foe? The elusive role of hepatic stellate cells in liver cancer

B Cogliati, CN Yashaswini, S Wang, D Sia… - Nature Reviews …, 2023 - nature.com
Liver fibrosis is a substantial risk factor for the development and progression of liver cancer,
which includes hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma …

Emerging targeted therapies for HER2-positive breast cancer

MF Mercogliano, S Bruni, FL Mauro, R Schillaci - Cancers, 2023 - mdpi.com
Simple Summary HER2-positive breast cancer (BC), which accounts for~ 20% of BC, is one
of the more aggressive and has the worst overall survival rate among them. These patients …

Spatial transcriptomics: technical aspects of recent developments and their applications in neuroscience and cancer research

HE Park, SH Jo, RH Lee, CP Macks, T Ku… - Advanced …, 2023 - Wiley Online Library
Spatial transcriptomics is a newly emerging field that enables high‐throughput investigation
of the spatial localization of transcripts and related analyses in various applications for …

Stgnnks: identifying cell types in spatial transcriptomics data based on graph neural network, denoising auto-encoder, and k-sums clustering

L Peng, X He, X Peng, Z Li, L Zhang - Computers in Biology and Medicine, 2023 - Elsevier
Background: Spatial transcriptomics technologies fully utilize spatial location information,
tissue morphological features, and transcriptional profiles. Integrating these data can greatly …

Omics approaches for the assessment of biological responses to nanoparticles

Y Abdelkader, L Perez-Davalos, R LeDuc… - Advanced Drug Delivery …, 2023 - Elsevier
Nanotechnology has enabled the development of innovative therapeutics, diagnostics, and
drug delivery systems. Nanoparticles (NPs) can influence gene expression, protein …

Spatial transcriptomics technology in cancer research

Q Yu, M Jiang, L Wu - Frontiers in Oncology, 2022 - frontiersin.org
In recent years, spatial transcriptomics (ST) technologies have developed rapidly and have
been widely used in constructing spatial tissue atlases and characterizing spatiotemporal …

Spatial transcriptomics drives a new era in plant research

R Yin, K Xia, X Xu - The Plant Journal, 2023 - Wiley Online Library
Spatial transcriptomics drives a new era in plant research - Yin - 2023 - The Plant Journal - Wiley
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