Role of SARS-CoV-2 spike-protein-induced activation of microglia and mast cells in the pathogenesis of neuro-COVID

TC Theoharides, D Kempuraj - Cells, 2023 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19). About 45% of COVID-19 patients experience several symptoms a …

Mast cell-mediated immune regulation in health and disease

KN Dileepan, VV Raveendran, R Sharma… - Frontiers in …, 2023 - frontiersin.org
Mast cells are important components of the immune system, and they perform pro-
inflammatory as well as anti-inflammatory roles in the complex process of immune regulation …

Mast cell activation in lungs during SARS-CoV-2 infection associated with lung pathology and severe COVID-19

JYJ Tan, DE Anderson, APS Rathore… - The Journal of …, 2023 - Am Soc Clin Investig
Lung inflammation is a hallmark of Coronavirus disease 2019 (COVID-19) in patients who
are severely ill, and the pathophysiology of disease is thought to be immune mediated. Mast …

Recombinant SARS-CoV-2 spike protein stimulates secretion of chymase, tryptase, and IL-1β from human mast cells, augmented by IL-33

I Tsilioni, TC Theoharides - International Journal of Molecular Sciences, 2023 - mdpi.com
SARS-CoV-2 infects cells via its spike (S) protein binding to its surface receptor angiotensin-
converting enzyme 2 (ACE2) and results in the production of multiple proinflammatory …

Mast cells in the autonomic nervous system and potential role in disorders with dysautonomia and neuroinflammation

TC Theoharides, A Twahir, D Kempuraj - Annals of Allergy, Asthma & …, 2023 - Elsevier
Mast cells (MC) are ubiquitous in the body and are critical for allergic diseases, but also in
immunity and inflammation, as well as potential involvement in the pathophysiology of …

Dysregulated early transcriptional signatures linked to mast cell and interferon responses are implicated in COVID-19 severity

R MacCann, AAG Leon, G Gonzalez, MJ Carr… - Frontiers in …, 2023 - frontiersin.org
Background Dysregulated immune responses to severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection are thought to underlie the progression of coronavirus …

Coronavirus receptor expression profiles in human mast cells, basophils, and eosinophils

L Degenfeld-Schonburg, I Sadovnik, D Smiljkovic… - Cells, 2024 - mdpi.com
A major problem in SARS-CoV-2-infected patients is the massive tissue inflammation in
certain target organs, including the lungs. Mast cells (MC), basophils (BA), and eosinophils …

[HTML][HTML] Mast cell activation triggered by SARS-CoV-2 causes inflammation in brain microvascular endothelial cells and microglia

ML Wu, C Xie, X Li, J Sun, J Zhao… - Frontiers in Cellular and …, 2024 - frontiersin.org
SARS-CoV-2-induced excessive inflammation in brain leads to damage of blood-brain
barrier, hypoxic-ischemic injury, and neuron degeneration. The production of inflammatory …

Mechanisms of COVID-19 associated pulmonary thrombosis: a narrative review

CM Niculae, A Hristea, R Moroti - Biomedicines, 2023 - mdpi.com
COVID-19, the infectious disease caused by severe acute respiratory syndrome coronavirus-
2 (SARS-CoV-2), is frequently associated with pulmonary thrombotic events, especially in …

Mast cells selectively produce inflammatory mediators and impact the early response to Chlamydia reproductive tract infection

A Mayavannan, E Shantz, ID Haidl, J Wang… - Frontiers in …, 2023 - frontiersin.org
Introduction Chlamydia trachomatis (C. trachomatis) is a Gram-negative obligate
intracellular bacterium that causes reproductive tract complications in women, including …