At least half of all patients with heart failure (HF) are affected by frailty, a syndrome that limits
an individual ability to recover from acute stressors. While frailty affects up to 90% of patients …

Frailty is a global health problem that impacts clinical practice. It is complex, having a
physical and a cognitive component, and it is the result of many contributing factors. Frail …

Abstract Background and Aims There is little information on the incremental prognostic
importance of frailty beyond conventional prognostic variables in heart failure (HF) …

Background Implantable cardioverter-defibrillator (ICD) therapy is recommended to reduce
mortality risk in patients with heart failure with reduced ejection fraction (HFrEF). Frailty is …

Anthracyclines are essential adjuvant therapies for a variety of cancers, particularly breast,
gastric and esophageal cancers. Whilst prolonging cancer-related survival, these agents …

Aging is an important risk factor for the development of heart failure (HF) and half of patients
with HF have preserved ejection fraction (HFpEF) which is more common in elderly women …

Although inflammation is strongly associated with frailty, whether medications that lower
inflammation decrease frailty is unclear and randomized trial evidence is scant. We sought …

Background Frailty is increasingly recognized as a useful measure of vulnerability in older
adults. Multiple claims-based frailty indices (CFIs) can readily identify individuals with frailty …

Frailty is increasingly recognized as a salient condition in patients with heart failure (HF) as
previous studies have determined that frailty is highly prevalent and prognostically …

Background Frailty is a severe, common co‐morbidity associated with heart failure (HF) with
preserved ejection fraction (HFpEF). The impact of frailty on HFpEF outcomes may affect …