The physiological processes of cell growth, proliferation, differentiation, and apoptosis are
closely related to STAT3, and it has been demonstrated that aberrant STAT3 expression has …

For more than 50 years, evidence has accumulated that inflammation contributes to the
pathogenesis of hypertension. Immune cells have been observed in vessels and kidneys of …

Abstract The Tumor Immune Single Cell Hub 2 (TISCH2) is a resource of single-cell RNA-
seq (scRNA-seq) data from human and mouse tumors, which enables comprehensive …

Gene regulatory networks (GRNs) are key determinants of cell function and identity and are
dynamically rewired during development and disease. Despite decades of advancement …

In addition to their early-recognized functions in host defense and the clearance of apoptotic
cell debris, macrophages play vital roles in tissue development, homeostasis, and repair. If …

Monocytes influence multiple aspects of tumor progression, including antitumor immunity,
angiogenesis, and metastasis, primarily by infiltrating tumors, and differentiating into tumor …

Macrophages play a central role in orchestrating immune responses to foreign materials,
which are often responsible for the failure of implanted medical devices. Material topography …

The sphingolipid sphingosine-1-phosphate (S1P) is produced by sphingosine kinases to
either signal through intracellular targets or to activate a family of specific G-protein-coupled …

Macrophages are multifunctional immune cells whose functions depend on polarizable
phenotypes and the microenvironment. Macrophages have two phenotypes, including the …

Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a
complex immune-mediated disease of the gastrointestinal tract that increases morbidity and …