We discuss new approaches to the early detection of keratoconus and recent investigations
regarding the nature of its pathophysiology. We review the current evidence for its complex …

Corneal wound healing is a complex process involving cell death, migration, proliferation,
differentiation, and extracellular matrix remodeling. Many similarities are observed in the …

The vertebrate retina is a well-characterized and tractable model for studying neurogenesis.
Retinal neurons and glia are generated in a conserved sequence from a pool of multipotent …

Visual perception in humans occurs through absorption of electromagnetic radiation from
400 to 780 nm by photoreceptors in the retina. A photon of visible light carries a sufficient …

MicroRNAs (miRNAs) bind to complementary sequences within the 3′ untranslated region
(UTR) of mRNAs from hundreds of target genes, leading either to mRNA degradation or …

Oxidative stress is a major component of most major retinal diseases. Many extrinsic anti-
oxidative strategies have been insufficient at counteracting one of the predominant intrinsic …

Most regions of the vertebrate central nervous system develop by the sequential addition of
different classes of neurons and glia. This phenomenon has been best characterized in …

Glaucoma, a neurodegenerative disorder that leads to irreversible blindness, remains a
challenge because of its complex nature. MicroRNAs (miRNAs) are crucial regulators of …

Development of viral vectors capable of transducing photoreceptors by less invasive
methods than subretinal injection would provide a major advancement in retinal gene …

CD146, an endothelial biomarker, has been shown to be aberrantly upregulated during
pathological angiogenesis and functions as a coreceptor for vascular endothelial growth …