The skin, being the barrier organ of the body, is constitutively exposed to various stimuli
impacting its morphology and function. Senescent cells have been found to accumulate with …

Lines of evidence from several studies have shown that increases in life expectancy are now
accompanied by increased disability rate. The expanded lifespan of the aging population …

Accumulating evidence indicates that senescent cells play an important role in many age-
associated diseases. The pharmacological depletion of senescent cells (SCs) with a …

In recent years, cellular senescence has generated a lot of interest among researchers
because of its involvement in both the normal aging process and common human diseases …

Despite the growing interest by researchers into cellular senescence, a hallmark of cellular
aging, its role in human skin remains equivocal. The skin is the largest and most accessible …

At their proliferative limit, normal cells arrest and undergo replicative senescence, displaying
large cell size, flat morphology, and senescence-associated beta-galactosidase (SA-β-Gal) …

Cellular senescence is a fundamental, complex mechanism with an important protective role
present from embryogenesis to late life across all species. It limits the proliferative potential …

Telomeres are specialized nucleoprotein structures located at the end of linear
chromosomes and telomerase is the enzyme responsible for telomere elongation …

Importance An aging population is increasing the need for intensive care unit (ICU) beds.
The benefit of ICU admission for elderly patients remains a subject of debate; however, long …

Hepatocyte senescence is associated with liver fibrosis. However, the possibility of a direct,
causal relation between hepatocyte senescence and hepatic stellate cell (HSC) activation …