The tumor microenvironment (TME) is emerging as one of the primary barriers in cancer
therapy. Cancer-associated fibroblasts (CAF) are a common inhabitant of the TME in several …

Ovarian cancer is one of the most common gynecological malignancies. Upon initial
diagnosis, the majority of patients present with widespread metastatic growth within the …

Abstract miRNAs are a key component of the noncoding RNA family. The underlying
mechanisms involved in the interplay between the tumor microenvironment and cancer cells …

Cancer associated fibroblasts (CAFs) and tumor associated macrophages (TAMs) are
among the most important and abundant players of the tumor microenvironment. CAFs as …

Background High-grade serous tubo-ovarian cancer (HGSTOC) is characterised by
extensive inter-and intratumour heterogeneity, resulting in persistent therapeutic resistance …

Successful metastasis requires the co-evolution of stromal and cancer cells. We used stable
isotope labeling of amino acids in cell culture coupled with quantitative, label-free …

Ovarian cancer is the most lethal gynecological malignancy. It is usually diagnosed at a late
stage, with a 5-yr survival rate of< 30%. The majority of ovarian cancer cases are diagnosed …

High-grade serous ovarian cancers (HGSOC) have been subdivided into molecular
subtypes. The mesenchymal HGSOC subgroup, defined by stromal-related gene signatures …

Objective Periostin (POSTN) overexpression observed in various cancer types is correlated
with metastasis and tumor progression. However, its effect on the crosstalk between ovarian …

Simple Summary Cancer-associated fibroblasts (CAFs) play an important contributory role in
the microenvironment of tumors. They originate from different cells, have multiple pro-and …