COVID‐19 immunopathology: from acute diseases to chronic sequelae
The clinical manifestation of coronavirus disease 2019 (COVID‐19) mainly targets the lung
as a primary affected organ, which is also a critical site of immune cell activation by severe …
as a primary affected organ, which is also a critical site of immune cell activation by severe …
[HTML][HTML] Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2
Long COVID (LC) occurs after at least 10% of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infections, yet its etiology remains poorly understood. We used …
coronavirus 2 (SARS-CoV-2) infections, yet its etiology remains poorly understood. We used …
Immune signatures underlying post-acute COVID-19 lung sequelae
Severe coronavirus disease 2019 (COVID-19) pneumonia survivors often exhibit long-term
pulmonary sequelae, but the underlying mechanisms or associated local and systemic …
pulmonary sequelae, but the underlying mechanisms or associated local and systemic …
[HTML][HTML] The dark side of Tregs during aging
M Palatella, SM Guillaume, MA Linterman… - Frontiers in …, 2022 - frontiersin.org
In the last century, we have seen a dramatic rise in the number of older persons globally, a
trend known as the grey (or silver) tsunami. People live markedly longer than their …
trend known as the grey (or silver) tsunami. People live markedly longer than their …
SARS-CoV-2 vaccination enhances the effector qualities of spike-specific T cells induced by COVID-19
T cells are critical for immune protection against severe COVID-19, but it has remained
unclear whether repeated exposure to SARS-CoV-2 antigens delivered in the context of …
unclear whether repeated exposure to SARS-CoV-2 antigens delivered in the context of …
SARS-CoV-2 epitope–specific CD4+ memory T cell responses across COVID-19 disease severity and antibody durability
RW Nelson, Y Chen, OL Venezia, RM Majerus… - Science …, 2022 - science.org
CD4+ T cells are central to long-term immunity against viruses through the functions of T
helper 1 (TH1) and T follicular helper (TFH) cell subsets. To better understand the role of …
helper 1 (TH1) and T follicular helper (TFH) cell subsets. To better understand the role of …
[HTML][HTML] mRNA vaccine-induced T cells respond identically to SARS-CoV-2 variants of concern but differ in longevity and homing properties depending on prior …
While mRNA vaccines are proving highly efficacious against SARS-CoV-2, it is important to
determine how booster doses and prior infection influence the immune defense they elicit …
determine how booster doses and prior infection influence the immune defense they elicit …
Mild SARS-CoV-2 infection in rhesus macaques is associated with viral control prior to antigen-specific T cell responses in tissues
CE Nelson, S Namasivayam, TW Foreman… - Science …, 2022 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily replicates in
mucosal sites, and more information is needed about immune responses in infected tissues …
mucosal sites, and more information is needed about immune responses in infected tissues …
[HTML][HTML] The role of exposomes in the pathophysiology of autoimmune diseases II: Pathogens
A Vojdani, E Vojdani, AZ Rosenberg, Y Shoenfeld - Pathophysiology, 2022 - mdpi.com
In our continuing examination of the role of exposomes in autoimmune disease, we use this
review to focus on pathogens. Infections are major contributors to the pathophysiology of …
review to focus on pathogens. Infections are major contributors to the pathophysiology of …
[HTML][HTML] Machine learning identifies T cell receptor repertoire signatures associated with COVID-19 severity
T cell receptor (TCR) repertoires are critical for antiviral immunity. Determining the TCR
repertoire composition, diversity, and dynamics and how they change during viral infection …
repertoire composition, diversity, and dynamics and how they change during viral infection …