Genetic polymorphisms complicate COVID-19 therapy: pivotal role of HO-1 in cytokine storm

EW Fakhouri, SJ Peterson, J Kothari, R Alex, JI Shapiro… - Antioxidants, 2020 - mdpi.com
Coronaviruses are very large RNA viruses that originate in animal reservoirs and include
severe acute respiratory distress syndrome (SARS) and Middle East respiratory syndrome …

CC chemokine receptor 4 (CCR4) as a possible new target for therapy

J Bogacka, K Pawlik, K Ciapała… - International Journal of …, 2022 - mdpi.com
Chemokines and their receptors participate in many biological processes, including the
modulation of neuroimmune interactions. Approximately fifty chemokines are distinguished …

Targeting chemokines and chemokine receptors in multiple sclerosis and experimental autoimmune encephalomyelitis

S Dhaiban, M Al-Ani, NM Elemam… - Journal of …, 2020 - Taylor & Francis
Multiple sclerosis (MS) is an immune-mediated and neurodegenerative disorder that results
in inflammation and demyelination of the central nervous system (CNS). MS symptoms …

Targeting chemokine receptor CCR1 as a potential therapeutic approach for multiple myeloma

A Gilchrist, SL Echeverria - Frontiers in Endocrinology, 2022 - frontiersin.org
Multiple myeloma is an incurable plasma B-cell malignancy with 5-year survival rates
approximately 10-30% lower than other hematologic cancers. Treatment options include …

Targeted treatment of alcoholic liver disease based on inflammatory signalling pathways

B Wen, C Zhang, J Zhou, Z Zhang, Q Che… - Pharmacology & …, 2021 - Elsevier
Targeted therapy is an emerging treatment strategy for alcoholic liver disease (ALD).
Inflammation plays an important role in the occurrence and development of ALD, and is a …

Biased agonism at chemokine receptors

DS Eiger, N Boldizsar, CC Honeycutt, J Gardner… - Cellular signalling, 2021 - Elsevier
In the human chemokine system, interactions between the approximately 50 known
endogenous chemokine ligands and 20 known chemokine receptors (CKRs) regulate a …

Nano-based approaches in the development of antiviral agents and vaccines

Y Li, Y Xiao, Y Chen, K Huang - Life sciences, 2021 - Elsevier
Outbreaks and the rapid transmission of viruses, such as coronaviruses and influenza
viruses, are serious threats to human health. A major challenge in combating infectious …

Drug discovery of nucleos (t) ide antiviral agents: dedicated to Prof. Dr. Erik De Clercq on occasion of his 80th birthday

G Li, T Yue, P Zhang, W Gu, LJ Gao, L Tan - Molecules, 2021 - mdpi.com
Nucleoside and nucleotide analogues are essential antivirals in the treatment of infectious
diseases such as human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C …

[HTML][HTML] Recent advances in strategies to target the behavior of macrophages in wound healing

H Zheng, X Cheng, L Jin, S Shan, J Yang… - Biomedicine & …, 2023 - Elsevier
Chronic wounds and scar formation are widespread due to limited suitable remedies. The
macrophage is a crucial regulator in wound healing, controlling the onset and termination of …

Biologic therapies for asthma and allergic disease: past, present, and future

F Ramírez-Jiménez, GF Pavón-Romero… - Pharmaceuticals, 2023 - mdpi.com
The discovery of the mechanism underlying allergic disease, mouse models of asthma, and
bronchoscopy studies provided initial insights into the role of Th2-type cytokines, including …