Targeting oncoimmune drivers of cancer metastasis

C Kudo-Saito, Y Ozaki, H Imazeki, H Hayashi… - Cancers, 2021 - mdpi.com
Simple Summary Despite great advances in the detailed profiling of tumor cells and the
development of therapeutic agents, cancer metastasis is still a big hurdle in the treatment of …

CCR5Δ32 in Brazil: Impacts of a european genetic variant on a highly admixed population

B Kulmann-Leal, JH Ellwanger, JAB Chies - Frontiers in Immunology, 2021 - frontiersin.org
The genetic background of Brazilians encompasses Amerindian, African, and European
components as a result of the colonization of an already Amerindian inhabited region by …

[HTML][HTML] CCL5 might be a prognostic biomarker and associated with immuno-therapeutic efficacy in cancers: A pan-cancer analysis

Y Huang, L Wu, Y Sun, J Li, N Mao, Y Yang, M Zhao… - Heliyon, 2023 - cell.com
Abstract Purpose Chemokine ligand 5 (CCL5), a vital member of the CC chemokine family,
plays diverse roles in tumorigenesis, metastasis, and prognosis in various human tumors …

Repurpose but also (nano)-reformulate! The potential role of nanomedicine in the battle against SARS-CoV2

SN Tammam, S El Safy, S Ramadan, S Arjune… - Journal of Controlled …, 2021 - Elsevier
Abstract The coronavirus disease-19 (COVID-19), caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV2) has taken the world by surprise. To date, a …

Mitochondrial impairment: a link for inflammatory responses activation in the cardiorenal syndrome type 4

I Amador-Martínez, OE Aparicio-Trejo… - International Journal of …, 2023 - mdpi.com
Cardiorenal syndrome type 4 (CRS type 4) occurs when chronic kidney disease (CKD)
leads to cardiovascular damage, resulting in high morbidity and mortality rates …

High circulating SDF-1and MCP-1 levels and genetic variations in CXCL12, CCL2 and CCR5: Prognostic signature of immune recovery status in treated HIV-positive …

E Yeregui, C Viladés, P Domingo, A Ceausu… - …, 2020 - thelancet.com
Background The underlying mechanisms of incomplete immune reconstitution in treated HIV-
positive patients are very complex and may be multifactorial, but perturbation of chemokine …

Mogamulizumab-induced vitiligo in patients with Sézary syndrome: three cases

AS Algarni, C Ram-Wolff, M Bagot… - European Journal of …, 2021 - Springer
Background Mogamulizumab is a novel defucosylated monoclonal antibody targeting the
CC chemokine receptor 4 (CCR4) that eradicates Sézary cells via antibody-dependent …

A novel CXCR4-targeted diphtheria toxin nanoparticle inhibits invasion and metastatic dissemination in a head and neck squamous cell carcinoma mouse model

E Rioja-Blanco, A Gallardo, I Arroyo-Solera, P Álamo… - Pharmaceutics, 2022 - mdpi.com
Loco-regional recurrences and metastasis represent the leading causes of death in head
and neck squamous cell carcinoma (HNSCC) patients, highlighting the need for novel …

The strategies and challenges of CCR5 gene editing in hematopoietic stem and progenitor cells for the treatment of HIV

KV Karuppusamy, P Babu, S Thangavel - Stem Cell Reviews and Reports, 2021 - Springer
HIV infection continues to be a serious health issue with an alarming global spread, owing to
the fact that attempts at developing an effective vaccine or a permanent cure remains futile …

CCR5 and Inflammatory Storm

Y Lin, S Liu, Y Sun, C Chen, S Yang, G Pei, M Lin… - Ageing Research …, 2024 - Elsevier
Chemokines and their corresponding receptors play crucial roles in orchestrating
inflammatory and immune responses, particularly in the context of pathological conditions …