Comprehensive analysis of chemokine gene polymorphisms in Korean children with autoimmune thyroid disease

C Shin, IC Baek, WK Cho, TG Kim, BK Suh - Scientific Reports, 2023 - nature.com
Chemokines are chemotactic cytokines that can cause directed migration of leukocytes. The
aim of this study was to examine differences in single nucleotide polymorphisms (SNP) of …

[PDF][PDF] Drug repurposing clinical trials in the search for life-saving Covid-19 therapies; research targets and methodological and ethical issues

FJR Paumgartten, IF Delgado… - Vigilância Sanitária em …, 2020 - redalyc.org
Introduction: So far, there is no vaccine, nor are there effective drugs to treat COVID-19, an
emerging viral respiratory infection deadlier than influenza. Objective: To take a snapshot …

Novel peptide-based PET probe for non-invasive imaging of CXC chemokine receptor type 4 (CXCR4) in tumors

AM Trotta, M Aurilio, C D'Alterio, C Ierano… - Journal of Medicinal …, 2021 - ACS Publications
The recently reported CXCR4 antagonist 3 (Ac-Arg-Ala-[DCys-Arg-2Nal-His-Pen]-CO2H)
was investigated as a molecular scaffold for a CXCR4-targeted positron emission …

The strategies and challenges of CCR5 gene editing in hematopoietic stem and progenitor cells for the treatment of HIV

KV Karuppusamy, P Babu, S Thangavel - Stem Cell Reviews and Reports, 2021 - Springer
HIV infection continues to be a serious health issue with an alarming global spread, owing to
the fact that attempts at developing an effective vaccine or a permanent cure remains futile …

The oral CXCR4 inhibitor X4-136 improves tumor control and reduces toxicity in cervical cancer treated with radiation therapy and concurrent chemotherapy

N Chaudary, RP Hill, L Stulik, M Milosevic - International Journal of …, 2021 - Elsevier
Purpose Cervical cancer is a global health problem. Despite the growth of prevention
programs, there is an important need to improve the effectiveness of treatment for patients …

From Berlin to London: HIV-1 reservoir reduction following stem cell transplantation

CA Prator, J Donatelli, TJ Henrich - Current HIV/AIDS Reports, 2020 - Springer
Abstract Purpose of Review Few interventional strategies lead to significant reductions in
HIV-1 reservoir size or prolonged antiretroviral (ART)-free remission. Allogeneic stem cell …

[HTML][HTML] Neutrophils as potential therapeutic targets for breast cancer

YT Gong, LJ Zhang, YC Liu, M Tang, JY Lin… - Pharmacological …, 2023 - Elsevier
Breast cancer (BC) remains the foremost cause of cancer mortality globally, with neutrophils
playing a critical role in its pathogenesis. As an essential tumor microenvironment (TME) …

Progression of radio-labeled molecular imaging probes targeting chemokine receptors

H Yi, L Qin, X Ye, J Song, J Ji, T Ye, J Li, L Li - Critical Reviews in Oncology …, 2024 - Elsevier
Chemokine receptors are significantly expressed in the surface of most inflammatory cells
and tumor cells. Guided by chemokines, inflammatory cells which express the relevant …

Mogamulizumab-induced vitiligo in patients with Sézary syndrome: three cases

AS Algarni, C Ram-Wolff, M Bagot… - European Journal of …, 2021 - Springer
Background Mogamulizumab is a novel defucosylated monoclonal antibody targeting the
CC chemokine receptor 4 (CCR4) that eradicates Sézary cells via antibody-dependent …

Life-long passion for antiviral research and drug development: 80th birthday of Prof. Dr. Erik De Clercq

G Li, M Xu, T Yue, W Gu, L Tan - Biochemical Pharmacology, 2021 - Elsevier
Since the 1950s, great efforts have been made to develop antiviral agents against many
infectious diseases such as human immunodeficiency virus (HIV), hepatitis B virus (HBV) …