Background Asthma is a chronic inflammatory disease that shows a time-of-day response to
variations in symptoms/severity. However, how the lung circadian clock influences time-of …

Objectives Chemokine receptor antagonists are being explored for their therapeutic
potential in various disease processes. As the chemokine (C–C motif) receptor 2 (CCR2) …

The ability of tumors to establish a pro-tumorigenic microenvironment is becoming an
important point of investigation in the search for new therapeutics. Tumors form …

The highly malignant nature of lung adenocarcinoma (LUAD) makes its early diagnosis and
prognostic assessment particularly important. However, whether the CXC subfamily of …

Background This study aimed to investigate the relationship between single nucleotide
polymorphisms (SNPs) at the microRNA target sequence in CXCR4 and the susceptibility to …

Chemokines are soluble mediators that are expressed on immune and non-immune cells in
various species, and are critical for their survival and homeostasis. They are key players in …

Traumatic brain injury (TBI) is a common injury caused by external forces that lead to
damaged brain function or pathological changes in the brain tissue. To explore the …

Until the year 1500 CE, Brazil was inhabited only by Native Americans belonging to different
linguistic groups, distributed along the coast and hinterland of the country. This scenario …

G protein-coupled receptors (GPCRs) are the largest family of cell membrane receptors
involved in modulating almost all physiological processes by transducing extracellular …

Chronic inflammation triggers a cytokine or chemokine storm in the tissue microenvironment.
The unresolved, persistent inflammatory microenvironment has a tendency to initiate tumors …