The mitochondrial ribosome (mitoribosome) is a multicomponent machine that has unique
structural features. Biogenesis of the human mitoribosome includes correct maturation and …

Schizosaccharomyces pombe (fission yeast) is an attractive model for mitochondrial
research. The organism resembles human cells in terms of mitochondrial inheritance …

The human mitochondrial ribosome contains three [2Fe–2S] clusters whose assembly
pathway, role, and implications for mitochondrial and metabolic diseases are unknown …

The crotonase fold is generated by a framework of four repeats of a ββα-unit, extended by
two helical regions. The active site of crotonase superfamily (CS) enzymes is located at the …

Mitochondrial rRNA modifications are essential for mitoribosome assembly and its proper
function. The m4C methyltransferase METTL15 maintains mitochondrial homeostasis by …

Ribosome biogenesis is a key process in all organisms. It relies on coordinated work of
multiple proteins and RNAs, including an array of assembly factors. Among them, the …

The mitochondrial ribosome (mitoribosome) has diverged drastically from its evolutionary
progenitor, the bacterial ribosome. Structural and compositional diversity is particularly …

Mitochondrial gene expression relies on mitoribosomes to translate mitochondrial mRNAs.
The biogenesis of mitoribosomes is an intricate process involving multiple assembly factors …

The mitoribosome translates mitochondrial mRNAs and regulates energy conversion that is
a signature of aerobic life forms. We present a 2.2 Å resolution structure of human …

Complexome profiling (CP) is a powerful tool for systematic investigation of protein
interactors that has been primarily applied to study the composition and dynamics of …