The COVID-19 pandemic has resulted in upwards of 6.8 million deaths over the past three
years, and the frequent emergence of variants continues to strain global health. Although …

Over the last two decades the world has witnessed the global spread of two genetically
related highly pathogenic coronaviruses, severe acute respiratory syndrome coronavirus …

ORF8 is an accessory protein encoded by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2). Consensus regarding the biological functions of ORF8 is lacking, largely …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encodes six accessory
proteins (3a, 6, 7a, 7b, 8, and 9b) for which limited information is available on their role in …

Knockout of the ORF8 protein has repeatedly spread through the global viral population
during SARS-CoV-2 evolution. Here we use both regional and global pathogen sequencing …

Small animal models have been a challenge for the study of SARS-CoV-2 transmission, with
most investigators using golden hamsters or ferrets. Mice have the advantages of low cost …

SARS-CoV-2 has caused an estimated 7 million deaths worldwide to date. A secreted SARS-
CoV-2 accessory protein, known as open reading frame 8 (ORF8), elicits inflammatory …

Severe cases of SARS-CoV-2 infection are characterized by an immune response that leads
to the overproduction of pro-inflammatory cytokines, resulting in lung damage …

Introduction: Open Reading Frame 8 (ORF8) is a 121 amino acid length SARS-CoV-2
specific accessory protein that plays crucial roles in viral infectivity, and pathogenesis …

The recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
caused serious harm to human health and struck a blow to global economic development …