Drug treatment of COVID-19 infection

G Lui, G Guaraldi - Current opinion in pulmonary medicine, 2023 - journals.lww.com
Drug treatment of COVID-19 infection : Current Opinion in Pulmonary Medicine Drug treatment
of COVID-19 infection : Current Opinion in Pulmonary Medicine Log in or Register Subscribe to …

Oral Molnupiravir and Nirmatrelvir/Ritonavir for the Treatment of COVID-19: A Literature Review with a Focus on Real-World Evidence

I Karniadakis, N Mazonakis, C Tsioutis… - Infectious Disease …, 2023 - mdpi.com
Vaccines remain the cornerstone of medical prevention and are highly effective in reducing
the risk of severe disease and death due to coronavirus disease 2019 (COVID-19). In the …

Real-world evidence of the top 100 prescribed drugs in the USA and their potential for drug interactions with nirmatrelvir; ritonavir

J Gerhart, F Draica, M Benigno, J Atkinson… - The AAPS Journal, 2023 - Springer
Nirmatrelvir (coadministered with ritonavir as PAXLOVIDTM) reduces the risk of COVID-19-
related hospitalizations and all-cause death in individuals with mild-to-moderate COVID-19 …

Potential drug–drug interactions among US adults treated with nirmatrelvir/ritonavir: A cross‐sectional study of the National Covid Cohort Collaborative (N3C)

X Xiao, HB Mehta, J Curran… - … : The Journal of …, 2023 - Wiley Online Library
Abstract Study Objective To estimate the prevalence of potential moderate to severe drug–
drug interactions (DDIs) involving nirmatrelvir/ritonavir, identify interacting medications, and …

[HTML][HTML] Drug-drug interaction with oral antivirals for the early treatment of COVID-19

A Vuorio, F Raal, PT Kovanen - International Journal of Infectious …, 2023 - ncbi.nlm.nih.gov
We read with interest the Danish population-based study estimating the risk of significant
drug-drug interactions (DDIs) with the antiviral component, nirmatrelvir, of the drug …

[HTML][HTML] Hospitalization among patients treated with molnupiravir: A retrospective study of administrative data

G Prajapati, A Das, Y Sun, E Fonseca - Clinical Therapeutics, 2023 - Elsevier
Purpose Molnupiravir is an oral antiviral agent authorized for emergency use to treat mild to
moderate cases of coronavirus disease 2019 (COVID-19) in adults at high risk for …

SRX3177, a CDK4/6-PI3K-BET inhibitor, in combination with an RdRp inhibitor, Molnupiravir, or an entry inhibitor MU-UNMC-2, has potent antiviral activity against the …

K Pandey, A Acharya, D Pal, P Jain, K Singh… - Antiviral Research, 2024 - Elsevier
Despite considerable progress in developing vaccines and antivirals to combat COVID-19,
the rapid mutations of the SARS-CoV-2 genome have limited the durability and efficacy of …

Ritonavir: 25 Years' Experience of Concomitant Medication Management. A Narrative Review

R Quercia, G Di Perri, C Pein, J Bodie… - Infectious Diseases and …, 2024 - Springer
Ritonavir is a potent inhibitor of the cytochrome P450 3A4 enzyme and is commonly used as
a pharmacokinetic (PK) enhancer in antiviral therapies because it increases bioavailability …

[HTML][HTML] Associations Between COVID-19, Delirium, and 1-Year Mortality: Exploring Influences on Delirium Incidence in COVID-19 Patients

Y Jang, HJ Hur, W Myung, EJ Park… - Journal of Korean …, 2024 - synapse.koreamed.org
Background This study investigated the relationship between coronavirus disease 2019
(COVID-19), delirium, and 1-year mortality. Factors associated with delirium in COVID-19 …

Absolute Risk Reductions in COVID-19 Antiviral Medication Clinical Trials

RB Brown - Pharmacoepidemiology, 2023 - mdpi.com
COVID-19 antiviral medications approved or authorized for emergency use by the US Food
and Drug Administration are reported to have high efficacy in preventing severe illness …