Polycystic ovary syndrome (PCOS) is among the most common disorders in women of
reproductive age, affecting up to 15% worldwide, depending on the diagnostic criteria …

Compared to the conventional linkage mapping, linkage disequilibrium (LD)‐mapping,
using the nonrandom associations of loci in haplotypes, is a powerful high‐resolution …

Most common human traits and diseases have a polygenic pattern of inheritance: DNA
sequence variants at many genetic loci influence the phenotype. Genome-wide association …

Case-parent trios were used in a genome-wide association study of cleft lip with and without
cleft palate. SNPs near two genes not previously associated with cleft lip with and without …

While it is apparent that rare variation can play an important role in the genetic architecture
of autism spectrum disorders (ASDs), the contribution of common variation to the risk of …

Background Hyperuricaemia, a highly heritable trait, is a key risk factor for gout. We aimed to
identify novel genes associated with serum uric acid concentration and gout. Methods …

The t-distributed stochastic neighbor embedding t-SNE is a new dimension reduction and
visualization technique for high-dimensional data. t-SNE is rarely applied to human genetic …

Previous studies have narrowed the interval containing PSORS1, the psoriasis-susceptibility
locus in the major histocompatibility complex (MHC), to an∼ 300-kb region containing HLA …

Kawasaki disease is a systemic vasculitis of unknown etiology, with clinical observations
suggesting a substantial genetic contribution to disease susceptibility. We conducted a …

Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder. To date four
genes have been established to either cause early-onset autosomal-dominant AD (APP …