A fast, scalable and versatile tool for analysis of single-cell omics data
Single-cell omics technologies have revolutionized the study of gene regulation in complex
tissues. A major computational challenge in analyzing these datasets is to project the large …
tissues. A major computational challenge in analyzing these datasets is to project the large …
[HTML][HTML] Role of H3K4 monomethylation in gene regulation
Highlights•H3K4 monomethylation (H3K4me1) is a conserved histone mark.•H3K4me1 is
implicated in various regulatory stages of gene regulation.•Data supporting and opposing a …
implicated in various regulatory stages of gene regulation.•Data supporting and opposing a …
[HTML][HTML] Conserved and divergent gene regulatory programs of the mammalian neocortex
Divergence of cis-regulatory elements drives species-specific traits, but how this manifests in
the evolution of the neocortex at the molecular and cellular level remains unclear. Here we …
the evolution of the neocortex at the molecular and cellular level remains unclear. Here we …
Mapping the chromatin accessibility landscape of zebrafish embryogenesis at single-cell resolution by SPATAC-seq
Currently, the dynamic accessible elements that determine regulatory programs responsible
for the unique identity and function of each cell type during zebrafish embryogenesis lack …
for the unique identity and function of each cell type during zebrafish embryogenesis lack …
Nano-CUT&Tag for multimodal chromatin profiling at single-cell resolution
JR Bárcenas-Walls, F Ansaloni, B Hervé… - Nature …, 2024 - nature.com
The ability to comprehensively analyze the chromatin state with single-cell resolution is
crucial for understanding gene regulatory principles in heterogenous tissues or during …
crucial for understanding gene regulatory principles in heterogenous tissues or during …
Simultaneous single-cell analysis of 5mC and 5hmC with SIMPLE-seq
Abstract Dynamic 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)
modifications to DNA regulate gene expression in a cell-type-specific manner and are …
modifications to DNA regulate gene expression in a cell-type-specific manner and are …
scNanoSeq-CUT&Tag: a single-cell long-read CUT&Tag sequencing method for efficient chromatin modification profiling within individual cells
Chromatin modifications are fundamental epigenetic marks that determine genome
functions, but it remains challenging to profile those of repetitive elements and complex …
functions, but it remains challenging to profile those of repetitive elements and complex …
Droplet Hi-C enables scalable, single-cell profiling of chromatin architecture in heterogeneous tissues
Current methods for analyzing chromatin architecture are not readily scalable to
heterogeneous tissues. Here we introduce Droplet Hi-C, which uses a commercial …
heterogeneous tissues. Here we introduce Droplet Hi-C, which uses a commercial …
Droplet-based single-cell sequencing: Strategies and applications
Y Shang, Z Wang, L Xi, Y Wang, M Liu, Y Feng… - Biotechnology …, 2024 - Elsevier
Notable advancements in single-cell omics technologies have not only addressed
longstanding challenges but also enabled unprecedented studies of cellular heterogeneity …
longstanding challenges but also enabled unprecedented studies of cellular heterogeneity …
[HTML][HTML] Evaluating Methods for the Prediction of Cell Type-Specific Enhancers in the Mammalian Cortex
Identifying cell type-specific enhancers in the brain is critical to building genetic tools for
investigating the mammalian brain. Computational methods for functional enhancer …
investigating the mammalian brain. Computational methods for functional enhancer …