Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are
not translated into proteins. Since their discovery, ncRNAs have emerged as important …

Fibrosis progression in the lung commonly results in impaired functional gas exchange,
respiratory failure, or even death. In addition to the aberrant activation and differentiation of …

Functional studies of the RNA N 6-methyladenosine (m6A) modification have been limited
by an inability to map individual m6A-modified sites in whole transcriptomes. To enable such …

Augmented glycolysis due to metabolic reprogramming in lung myofibroblasts is critical to
their profibrotic phenotype. The primary glycolysis byproduct, lactate, is also secreted into …

Background Circular RNA (circRNA) has been implicated in various diseases; however, its
role in atopic dermatitis (AD) or psoriasis remains unclear. Objective We sought to determine …

Idiopathic pulmonary fibrosis (IPF) is characterized by lung scarring and has no effective
treatment. Fibroblast-to-myofibroblast differentiation and myofibroblast proliferation and …

Long non-coding RNAs (lncRNAs) are involved in numerous biological processes and are
pivotal mediators of the immune response, yet little is known about their properties at the …

Sepsis presents as a severe infectious disease frequently documented in clinical settings.
Characterized by its systemic inflammatory response syndrome, sepsis has the potential to …

Pro-inflammatory M1 macrophages, via activating hepatic stellate cells, contribute to liver
fibrosis. In this study, we examined the mechanism and the significance of a signaling axis …

Hyperactive and damaging inflammation is a hallmark of severe rather than mild
Coronavirus disease 2019 (COVID-19). To uncover key inflammatory differentiators between …