Since the initial clinical approval in the late 1990s and remarkable anticancer effects for
certain types of cancer, molecular targeted therapy utilizing small molecule agents or …

Non-small-cell lung cancer (NSCLC) is one of the most common malignancies and the
leading causes of cancer-related death worldwide. Despite many therapeutic advances in …

Colorectal cancer (CRC), which shows a high degree of heterogeneity, is the third most
deadly cancer worldwide. Mutational activation of KRASG12D occurs in approximately 10 …

Activating point mutations in Anaplastic Lymphoma Kinase (ALK) have positioned ALK as
the only mutated oncogene tractable for targeted therapy in neuroblastoma. Cells with these …

Simple Summary Despite an initial response to therapy, many lung cancer patients
inevitably develop resistance to therapy leading to decreased duration of response and …

Despite recent advances in molecular therapeutics, lung cancer is still a leading cause of
cancer deaths. Currently, limited targeted therapy options and acquired drug resistance …

Posttranslational modifications (PTMs), such as phosphorylation, methylation, ubiquitination,
and acetylation, are important in governing protein expression levels. Proteolysis targeting …

Despite significant progress in clinical management, drug resistance remains a major
obstacle. Recent research based on protein degradation to restrain drug resistance has …

Background Breast cancer is the most frequently diagnosed cancer and a common cause of
cancer-related death in women. It is well recognized that obesity is associated with an …

Abstract EGFR exon 20 insertion (20ins)-positive non-small-cell lung cancer (NSCLC) is an
uncommon disease with limited therapeutic options and dismal prognosis. Here we report …