Innate immunity and interferon in SARS-CoV-2 infection outcome
Innate immunity and the actions of type I and III interferons (IFNs) are essential for protection
from SARS-CoV-2 and COVID-19. Each is induced in response to infection and serves to …
from SARS-CoV-2 and COVID-19. Each is induced in response to infection and serves to …
Interferon at the crossroads of SARS-CoV-2 infection and COVID-19 disease
CE Samuel - Journal of Biological Chemistry, 2023 - ASBMB
A novel coronavirus now known as SARS-CoV-2 emerged in late 2019, possibly following a
zoonotic crossover from a coronavirus present in bats. This virus was identified as the …
zoonotic crossover from a coronavirus present in bats. This virus was identified as the …
Omicron Spike confers enhanced infectivity and interferon resistance to SARS-CoV-2 in human nasal tissue
Omicron emerged following COVID-19 vaccination campaigns, displaced previous SARS-
CoV-2 variants of concern worldwide, and gave rise to lineages that continue to spread …
CoV-2 variants of concern worldwide, and gave rise to lineages that continue to spread …
Endogenous IFITMs boost SARS-coronavirus 1 and 2 replication whereas overexpression inhibits infection by relocalizing ACE2
Opposing effects of interferon-induced transmembrane proteins (IFITMs 1, 2 and 3) on SARS-
CoV-2 infection have been reported. The reasons for this are unclear and the role of IFITMs …
CoV-2 infection have been reported. The reasons for this are unclear and the role of IFITMs …
Genome-wide CRISPR activation screen identifies JADE3 as an antiviral activator of NF-kB–dependent IFITM3 expression
The innate immune system features a web of interacting pathways that require exquisite
regulation. To identify novel nodes in this immune landscape, we conducted a gain-of …
regulation. To identify novel nodes in this immune landscape, we conducted a gain-of …
Gasdermin D promotes influenza virus-induced mortality through neutrophil amplification of inflammation
S Speaks, MI McFadden, A Zani, A Solstad… - Nature …, 2024 - nature.com
Influenza virus activates cellular inflammasome pathways, which can be both beneficial and
detrimental to infection outcomes. Here, we investigate the function of the inflammasome …
detrimental to infection outcomes. Here, we investigate the function of the inflammasome …
The antiviral state of the cell: lessons from SARS-CoV-2
J Le Pen, CM Rice - Current Opinion in Immunology, 2024 - Elsevier
Highlights•Interferon-stimulated genes (ISGs) induce an antiviral state in cells.•Diverse
mechanisms restrict SARS-CoV-2 entry, replication, and release.•Some ISGs have intrinsic …
mechanisms restrict SARS-CoV-2 entry, replication, and release.•Some ISGs have intrinsic …
IFN-λ uniquely promotes CD8 T cell immunity against SARS-CoV-2 relative to type I IFN
AD Solstad, PJ Denz, AD Kenney, NS Mahfooz… - JCI insight, 2024 - insight.jci.org
Optimization of protective immune responses against SARS-CoV-2 remains an urgent
worldwide priority. In this regard, type III IFN (IFN-λ) restricts SARS-CoV-2 infection in vitro …
worldwide priority. In this regard, type III IFN (IFN-λ) restricts SARS-CoV-2 infection in vitro …
[HTML][HTML] Modulation of recovery from neonatal hyperoxic lung injury by sex as a biological variable
Recovery from lung injury during the neonatal period requires the orchestration of many
biological pathways. The modulation of such pathways can drive the developing lung …
biological pathways. The modulation of such pathways can drive the developing lung …
Dr Jekyll and Mr Hyde: From Two Branches of Immune Response to Three Types of Interferon Response
B Brown - 2023 - preprints.org
Interferons were the original prototype cytokine system discovered during research of the 20
th century. As the name suggests these were originally considered to be synthesised and …
th century. As the name suggests these were originally considered to be synthesised and …