How elite controllers and posttreatment controllers inform our search for an HIV-1 cure

JZ Li, JN Blankson - The Journal of clinical investigation, 2021 - Am Soc Clin Investig
A small percentage of people living with HIV-1 can control viral replication without
antiretroviral therapy (ART). These patients are called elite controllers (ECs) if they are able …

HIV antibody profiles in HIV controllers and persons with treatment-induced viral suppression

K Kammers, A Chen, DR Monaco… - Frontiers in …, 2021 - frontiersin.org
Introduction Low HIV viral load is associated with delayed disease progression and reduced
HIV transmission. HIV controllers suppress viral load to low levels in the absence of …

A role for antibodies in natural HIV control

A Moris, M Pereira, L Chakrabarti - Current Opinion in HIV and …, 2019 - journals.lww.com
A role for antibodies in natural HIV control : Current Opinion in HIV and AIDS A role for
antibodies in natural HIV control : Current Opinion in HIV and AIDS Log in or Register Subscribe …

[HTML][HTML] KIR3DL1/S1 allotypes contribute differentially to the development of Behçet disease

H Petrushkin, PJ Norman, E Lougee… - The Journal of …, 2019 - journals.aai.org
Behçet disease is a chronic, relapsing-remitting autoinflammatory syndrome with a strong
HLA-B* 51 association. In this paper, we describe a human cohort of 267 individuals with …

Contribution of the HIV-1 envelope glycoprotein to AIDS pathogenesis and clinical progression

A Valenzuela-Fernández, R Cabrera-Rodríguez… - Biomedicines, 2022 - mdpi.com
In the absence of antiviral therapy, HIV-1 infection progresses to a wide spectrum of clinical
manifestations that are the result of an entangled contribution of host, immune and viral …

The molecular basis of how buried human leukocyte antigen polymorphism modulates natural killer cell function

PM Saunders, BJ MacLachlan… - Proceedings of the …, 2020 - National Acad Sciences
Micropolymorphisms within human leukocyte antigen (HLA) class I molecules can change
the architecture of the peptide-binding cleft, leading to differences in peptide presentation …

Protective HLA-B57: T cell and natural killer cell recognition in HIV infection

CA Lobos, J Downing, LJ D'Orsogna… - Biochemical Society …, 2022 - portlandpress.com
Understanding the basis of the immune determinants controlling disease outcome is critical
to provide better care to patients and could be exploited for therapeutics and vaccine design …

Natural killer cells in antibody independent and antibody dependent HIV control

NF Bernard, S Kant, Z Kiani, C Tremblay… - Frontiers in …, 2022 - frontiersin.org
Infection with the human immunodeficiency virus (HIV), when left untreated, typically leads to
disease progression towards acquired immunodeficiency syndrome. Some people living …

Combined effects of HLA-B* 57/5801 elite suppressor CD8+ T cells and NK cells on HIV-1 replication

ME May, CW Pohlmeyer, AK Kwaa… - Frontiers in Cellular …, 2020 - frontiersin.org
Elite controllers or suppressors (ES) are HIV-1 infected individuals who maintain
undetectable viral loads without anti-retroviral therapy. The HLA-B* 57 allele is …

Monkeying around: using non-human primate models to study NK cell biology in HIV infections

C Manickam, SV Shah, J Nohara, G Ferrari… - Frontiers in …, 2019 - frontiersin.org
Natural killer (NK) cells are the major innate effectors primed to eliminate virus-infected and
tumor or neoplastic cells. Recent studies also suggest nuances in phenotypic and functional …