Structural biology of SARS-CoV-2: open the door for novel therapies

W Yan, Y Zheng, X Zeng, B He, W Cheng - Signal Transduction and …, 2022 - nature.com
Abstract Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the causative
agent of the pandemic disease COVID-19, which is so far without efficacious treatment. The …

Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses—are we our own worst enemy?

LYR Wong, S Perlman - Nature Reviews Immunology, 2022 - nature.com
Human coronaviruses cause a wide spectrum of disease, ranging from mild common colds
to acute respiratory distress syndrome and death. Three highly pathogenic human …

NF‐κB signaling in inflammation and cancer

T Zhang, C Ma, Z Zhang, H Zhang, H Hu - MedComm, 2021 - Wiley Online Library
Since nuclear factor of κ‐light chain of enhancer‐activated B cells (NF‐κB) was discovered
in 1986, extraordinary efforts have been made to understand the function and regulating …

SARS-CoV-2 infection drives an inflammatory response in human adipose tissue through infection of adipocytes and macrophages

GJ Martínez-Colón, K Ratnasiri, H Chen… - Science Translational …, 2022 - science.org
Obesity, characterized by chronic low-grade inflammation of the adipose tissue, is
associated with adverse coronavirus disease 2019 (COVID-19) outcomes, yet the …

Understanding the role of SARS-CoV-2 ORF3a in viral pathogenesis and COVID-19

J Zhang, A Ejikemeuwa, V Gerzanich, M Nasr… - Frontiers in …, 2022 - frontiersin.org
The ongoing SARS-CoV-2 pandemic has shocked the world due to its persistence, COVID-
19-related morbidity and mortality, and the high mutability of the virus. One of the major …

Possible pathogenesis and prevention of long COVID: SARS-CoV-2-induced mitochondrial disorder

TH Chen, CJ Chang, PH Hung - International journal of molecular …, 2023 - mdpi.com
Patients who have recovered from coronavirus disease 2019 (COVID-19) infection may
experience chronic fatigue when exercising, despite no obvious heart or lung abnormalities …

The battle between host and SARS-CoV-2: Innate immunity and viral evasion strategies

S Zhang, L Wang, G Cheng - Molecular therapy, 2022 - cell.com
The SARS-CoV-2 virus, the pathogen causing COVID-19, has caused more than 200 million
confirmed cases, resulting in more than 4.5 million deaths worldwide by the end of August …

The role of oxidative stress in the pathogenesis of infections with coronaviruses

C Gain, S Song, T Angtuaco, S Satta… - Frontiers in …, 2023 - frontiersin.org
Coronaviruses can cause serious respiratory tract infections and may also impact other end
organs such as the central nervous system, the lung and the heart. The coronavirus disease …

Neuroinvasion and anosmia are independent phenomena upon infection with SARS-CoV-2 and its variants

GD de Melo, V Perraud, F Alvarez… - Nature …, 2023 - nature.com
Anosmia was identified as a hallmark of COVID-19 early in the pandemic, however, with the
emergence of variants of concern, the clinical profile induced by SARS-CoV-2 infection has …

Honeysuckle (Lonicera japonica) and Huangqi (Astragalus membranaceus) Suppress SARS-CoV-2 Entry and COVID-19 Related Cytokine Storm in Vitro

YC Yeh, LH Doan, ZY Huang, LW Chu… - Frontiers in …, 2022 - frontiersin.org
COVID-19 is threatening human health worldwide but no effective treatment currently exists
for this disease. Current therapeutic strategies focus on the inhibition of viral replication or …