Lassa virus causes a hemorrhagic fever endemic in West Africa. The pathogenesis and the
immune responses associated with the disease are poorly understood, and no vaccine is …

Enveloped viruses exit their host cell by budding from a cellular membrane and thereby
spread from one cell to another. Virus budding in general involves the distortion of a cellular …

Bunyaviridae and Arenaviridae virus families include an important number of highly
pathogenic viruses for humans. They are enveloped viruses with negative stranded RNA …

Arenavirus pathogens cause a wide spectrum of diseases in humans ranging from central
nervous system disease to lethal hemorrhagic fevers with few treatment options. The reason …

The retinoic acid-inducible gene I product (RIG-I) is a cellular sensor of RNA virus infection
that regulates the cellular beta interferon (IFN-β) response. The nucleoproteins (NP) of …

Efficient human immunodeficiency virus type 1 (HIV-1) budding requires an interaction
between the PTAP late domain in the viral p6 Gag protein and the cellular protein TSG101 …

Matrix (M) proteins reportedly direct the budding of paramyxoviruses from infected cells. In
order to begin to characterize the assembly process for the highly lethal, emerging …

Arenaviruses comprise a diverse family of rodent-borne viruses that are responsible for
recurring and emerging outbreaks of viral hemorrhagic fevers worldwide. The Junín virus, a …

Lassa fever is a major threat in Western Africa. The large number of people living at risk for
this disease calls for the development of a vaccine against Lassa virus (LASV). We …

Hemorrhagic fevers (HF) resulting from pathogenic arenaviral infections have traditionally
been neglected as tropical diseases primarily affecting African and South American regions …