The family Arenaviridae contains several pathogens of major clinical importance. The Old
World (OW) arenavirus Lassa virus is endemic in West Africa and is estimated to cause up to …

Arenaviruses are enveloped, negative-strand RNA viruses. For several arenaviruses, virus-
like particle (VLP) formation requires the viral matrix Z protein. However, the mechanism by …

The arenavirus small RING finger Z protein has been shown to be the main driving force of
budding for several arenaviruses. This Z budding activity was found to be mediated by the …

Assembly of negative-strand RNA viruses occurs by budding from host plasma membranes.
The budding process involves association of the viral core or nucleocapsid with a region of …

The envelope glycoprotein of the Junín arenavirus (GP-C) mediates entry into target cells
through a pH-dependent membrane fusion mechanism. Unlike other class I viral fusion …

As an enveloped virus buds, the nascent viral capsid becomes wrapped in a plasma
membrane‐derived lipid envelope, and a membrane fission event is thus necessary to …

Tacaribe virus (TCRV) belongs to the Arenaviridae family. Its bisegmented negative-
stranded RNA genome encodes the nucleoprotein (N), the precursor of the envelope …

Hemorrhagic fever arenaviruses (HFA) pose important public health problems in regions
where they are endemic. Thus, Lassa virus (LASV) infects several hundred thousand …

Lassa fever (LF) is one of the most prevalent viral hemorrhagic fevers in West Africa
responsible for thousands of deaths annually. The BSL-4 containment requirement and lack …

Viral hemorrhagic fevers have captured the imagination of the public and made their way
into popular books and movies by virtue of their extreme virulence and mysterious origins …