Efficacy and safety of tirzepatide for treatment of overweight or obesity. A systematic review and meta-analysis

B Tan, XH Pan, HSJ Chew, RSJ Goh, C Lin… - International Journal of …, 2023 - nature.com
Background Recent studies suggest that tirzepatide, a dual glucose-dependent
insulinotropic-peptide (GIP) and glucagon-like peptide-1 receptor agonist (GLP-1 RA), has …

Steatotic liver disease: pathophysiology and emerging pharmacotherapies

M Kokkorakis, E Muzurović, Š Volčanšek… - Pharmacological …, 2024 - ASPET
Steatotic liver disease (SLD) displays a dynamic and complex disease phenotype.
Consequently, the metabolic dysfunction-associated steatotic liver disease …

Milestones in the journey towards addressing obesity; Past trials and triumphs, recent breakthroughs, and an exciting future in the era of emerging effective medical …

M Kokkorakis, A Katsarou, N Katsiki, CS Mantzoros - Metabolism, 2023 - Elsevier
The 21st century is characterized by an increasing incidence and prevalence of obesity and
the burden of its associated comorbidities, especially cardiometabolic diseases, which are …

Epicardial adipose tissue assessed by computed tomography and echocardiography are associated with adverse cardiovascular outcomes: a systematic review and …

B Chong, J Jayabaskaran, J Ruban, R Goh… - Circulation …, 2023 - Am Heart Assoc
Background: Epicardial adipose tissue (EAT) has garnered attention as a prognostic and
risk stratification factor for cardiovascular disease. This study, via meta-analyses, evaluates …

The silent burden of non‐alcoholic fatty liver disease in the elderly: a global burden of disease analysis

P Danpanichkul, CH Ng, MD Muthiah… - Alimentary …, 2023 - Wiley Online Library
Background Non‐alcoholic fatty liver disease (NAFLD) represents a significant health threat
worldwide. The growing trend towards an aging population, along with an alarming rise in …

Protein kinases: The key contributors in pathogenesis and treatment of nonalcoholic fatty liver disease-derived hepatocellular carcinoma

R Liu, M Qian, YY Cui - Metabolism, 2023 - Elsevier
Protein kinases (PKs), one of the largest protein families, can be further divided into different
groups based on their substrate or structure and function. PKs are important signaling …

Incidence of liver cancer in young adults according to the global burden of disease database 2019

P Danpanichkul, MB Aboona, B Sukphutanan… - Hepatology, 2024 - journals.lww.com
Objective: The worldwide burden of cancer is increasing in younger populations. However,
the epidemiology of primary liver cancer remains understudied in young adults compared to …

Does early time-restricted eating reduce body weight and preserve fat-free mass in adults? A systematic review and meta-analysis of randomized controlled trials

M He, B Li, M Li, S Gao - … & Metabolic Syndrome: Clinical Research & …, 2024 - Elsevier
Background This meta-analysis evaluated whether weight loss caused by early time-
restricted eating could promote fat mass loss while preserving fat-free mass, thereby leading …

New vaccines on the immediate Horizon for travelers: chikungunya and dengue vaccines

S Menon, A Wilder-Smith - Current Infectious Disease Reports, 2023 - Springer
Abstract Purpose of Review Both chikungunya and dengue virus infections are frequent in
international travelers to endemic areas. Recent Findings More than 11 chikungunya …

Trends and predictions of metabolic risk factors for acute myocardial infarction: findings from a multiethnic nationwide cohort

NWS Chew, B Chong, SM Kuo… - The Lancet Regional …, 2023 - thelancet.com
Background Understanding the trajectories of metabolic risk factors for acute myocardial
infarction (AMI) is necessary for healthcare policymaking. We estimated future projections of …