Tumor heterogeneity has been one of the most important factors leading to the failure of
conventional cancer therapies due to the accumulation of genetically distinct tumor-cell …

Background: Cancer stem cells (CSCs) are biologically characterized by self-renewal, multi-
directional differentiation and infinite proliferation, inducing anti-tumor drug resistance and …

This study shows that the androgen receptor agonistic potency is clearly concealed by the
effects of androgen receptor antagonists in a total sediment extract, demonstrating that …

Heterogeneity is a fundamental property of biological systems at all scales that must be
addressed in a wide range of biomedical applications, including basic biomedical research …

Combined single cell mass spectrometry and machine learning methods is demonstrated for
the first time to achieve rapid and reliable prediction of the phenotype of unknown single …

Only approximately 10% of genetically unselected patients with chemorefractory metastatic
colorectal cancer experience tumor regression when treated with the anti-epidermal growth …

Despite advances in the treatment of solid tumors, the prognosis of patients with many
cancers remains poor, particularly of those with primary and metastatic brain tumors. In the …

A major key to improvement of cancer therapy is the combination of drugs. Mixing drugs that
already exist on the market may offer an attractive alternative. Here we report on a new …

Treatments consisting of mixtures of pharmacological agents have been shown to have
superior effects to treatments involving single compounds. Given the vast amount of possible …

A major obstacle in precision cancer medicine is the inevitable resistance to targeted
therapies. Tremendous effort and progress has been made over the past few years to …