Despite advances in the treatment of solid tumors, the prognosis of patients with many
cancers remains poor, particularly of those with primary and metastatic brain tumors. In the …

A major key to improvement of cancer therapy is the combination of drugs. Mixing drugs that
already exist on the market may offer an attractive alternative. Here we report on a new …

Treatments consisting of mixtures of pharmacological agents have been shown to have
superior effects to treatments involving single compounds. Given the vast amount of possible …

A major obstacle in precision cancer medicine is the inevitable resistance to targeted
therapies. Tremendous effort and progress has been made over the past few years to …

Cancer treatment generally involves drugs used in combinations. Most previous work has
focused on identifying and understanding synergistic drug–drug interactions; however …

The ability to rapidly assess the efficacy of therapeutic strategies for incurable bone
metastatic prostate cancer is an urgent need. Pre-clinical in vivo models are limited in their …

An individual malignant tumor is composed of a heterogeneous collection of single cells with
distinct molecular and phenotypic features, a phenomenon termed intratumoral …

Single-nanoparticle (NP) combination chemotherapeutics are quickly emerging as attractive
alternatives to traditional chemotherapy due to their ability to increase drug solubility, reduce …

Simple Summary Acute myeloid leukemias (AML) results from the accumulation of genetic
and epigenetic alterations, often in the context of an aging hematopoietic environment. The …

Background A paucity of therapeutic options is available to treat men with metastatic
castration-resistant prostate cancer (mCRPC). However, recent developments in our …