Cancer is a clonal evolutionary process. This presents challenges for effective therapeutic
intervention, given the constant selective pressure toward drug resistance. Mathematical …

One of the greatest challenges in biomedical research, drug discovery and diagnostics is
understanding how seemingly identical cells can respond differently to perturbagens …

Combinations of therapies are being actively pursued to expand therapeutic options and
deal with cancer's pervasive resistance to treatment. Research efforts to discover effective …

The future of cancer treatment lies in personalized strategies designed to specifically target
tumorigenic cell populations present in an individual. Although recent advances in directed …

Drug resistance remains one of the greatest challenges facing precision oncology today.
Despite the vast array of resistance mechanisms that cancer cells employ to subvert the …

The success of targeted cancer therapy is limited by drug resistance that can result from
tumor genetic heterogeneity. The current approach to address resistance typically involves …

Hundreds of trials are being conducted to evaluate combination of newer targeted drugs as
well as immunotherapy. Our aim was to compare efficacy and safety of combination versus …

Highlights•Description of the key general principles of RTK co-activation in
cancer.•Hierarchical RTK networks maintain robust signalling and drive drug resistance.• …

Extranodal dissemination is an important feature of aggressive B-cell lymphoma. Owing to
the lack of available animal models, the study on extranodal dissemination of lymphoma is …

Drug candidates exhibiting well-defined pharmacokinetic and pharmacodynamic profiles
that are otherwise safe often fail to demonstrate proof-of-concept in phase II and III trials …