Cytokine dysregulation is believed to play a key role in the remodeling of the immune
system at older age, with evidence pointing to an inability to fine-control systemic …

Increased cardiovascular disease in aging is partly a consequence of the vascular
endothelial cell (EC) senescence and associated vascular dysfunction. In this contest, EC …

Ten years ago we first proposed the Alzheimer's disease (AD) mitochondrial cascade
hypothesis. This hypothesis maintains that gene inheritance defines an individual's baseline …

We use a genome-wide association of 1 million parental lifespans of genotyped subjects
and data on mortality risk factors to validate previously unreplicated findings near CDKN2B …

The human gut microbiome is a collection of bacteria, protozoa, fungi, and viruses that
coexist in our bodies and are essential in protective, metabolic, and physiologic functions of …

Longevity and healthy aging are among the most complex phenotypes studied to date. The
heritability of age at death in adulthood is approximately 25%. Studies of exceptionally long …

Background. The genetic contribution to longevity in humans has been estimated to range
from 15% to 25%. Only two genes, APOE and FOXO3, have shown association with …

Healthy aging and longevity in humans are modulated by a lucky combination of genetic
and non-genetic factors. Family studies demonstrated that about 25% of the variation in …

Here we summarize the latest data on genetic and epigenetic contributions to human aging
and longevity. Whereas environmental and lifestyle factors are important at younger ages …

Sardinia, Italy, has a high prevalence of residents who live more than 100 years. The
reasons for longevity in this isolated region are currently unknown. Gut microbiota may hold …