C-type natriuretic peptide (CNP) is an autocrine and paracrine mediator released by
endothelial cells, cardiomyocytes and fibroblasts that regulates vital physiological functions …

Measurement of natriuretic peptides (NPs) has proven its clinical value as biomarker,
especially in the context of heart failure (HF). In contrast, a state of partial NP deficiency …

Aims C-type natriuretic peptide (CNP) is an essential endothelium-derived signalling
species that governs vascular homoeostasis; CNP is also expressed in the heart but an …

Although diabetes mellitus (DM) causes cardiomyopathy and exacerbates heart failure, the
underlying molecular mechanisms for diabetic cardiomyopathy/heart failure are poorly …

Heart failure (HF) with preserved ejection fraction (HFpEF) is a major public health problem
with cases projected to double over the next two decades. There are currently no US Food …

Pulmonary hypertension (PH) due to left ventricular heart failure (LV-HF) is a disabling and
life-threatening disease for which there is currently no single marketed pharmacological …

What is known and objective Essential hypertension (EH) is a common disease exhibiting
large individual difference in occurrence, development and treatment response. Genetic …

Background: Pulmonary hypertension (PH) is a multi-faceted disease characterised by
vascular remodelling and elevated pressure in the pulmonary arteries. Whilst targeted …

Hypertension, which affects about one-third of adults worldwide, is a major risk factor for the
morbidity and mortality associated with cardiovascular diseases (CVDs) and end-stage …

To the Editor, In a recent issue of the journal, Agrawal and colleagues1 demonstrated that
natriuretic peptide receptor C (NPRC) may contribute to right ventricular (RV) remodelling in …