The molecular processes underlying human health and disease are highly complex. Often,
genetic and environmental factors contribute to a given disease or phenotype in a non …

Induced pluripotent stem cells (iPSCs) are valuable in disease modeling because of their
potential to expand and differentiate into virtually any cell type and recapitulate key aspects …

The genetic basis of most traits is highly polygenic and dominated by non-coding alleles. It is
widely assumed that such alleles exert small regulatory effects on the expression of cis …

Bulk-tissue molecular quantitative trait loci (QTLs) have been the starting point for
interpreting disease-associated variants, and context-specific QTLs show particular …

Detecting allelic imbalance at the isoform level requires accounting for inferential
uncertainty, caused by multi-mapping of RNA-seq reads. Our proposed method, SEESAW …

Tens of thousands of genetic variants associated with gene expression (cis-eQTLs) have
been discovered in the human population. These eQTLs are active in various tissues and …

Thousands of common genetic variants in the human population have been associated with
disease risk and phenotypic variation by genome-wide association studies (GWAS) …

Background Expression quantitative trait loci (eQTL) studies provide insights into regulatory
mechanisms underlying disease risk. Expanding studies of gene regulation to …

Summary lncRNA research is passing the stage of enumerating lncRNAs or recording
simplified on-off expression switches. Mechanistic analyses are starting to reveal …

Besnoitia besnoiti-infected bulls may develop severe systemic clinical signs and orchitis that
may ultimately cause sterility during the acute infection. Macrophages might play a relevant …