Congenital anomalies of the kidney and urinary tract (CAKUT) comprise a large variety of
malformations that arise from defective kidney or urinary tract development and frequently …

A kidney organoid is a three-dimensional (3D) cellular aggregate grown from stem cells in
vitro that undergoes self-organization, recapitulating aspects of normal renal development to …

Nephrons are the functional units which comprise the kidney. Each nephron contains a
number of physiologically unique populations of specialized epithelial cells that are …

In humans born at term, maximal nephron number is reached by the time nephrogenesis is
completed—at approximately 36 weeks' gestation. The number of nephrons does not …

Despite significant advances in understanding nephron segment patterning, many questions
remain about the underlying genes and signaling pathways that orchestrate renal progenitor …

Background The proximal tubule plays a major role in electrolyte homeostasis. Previous
studies have shown that HNF4A regulates reabsorption-related genes and promotes …

Kidney disease is a global health crisis affecting more than 850 million people worldwide. In
the United States, annual Medicare expenditures for kidney disease and organ failure …

Nephron progenitor cells (NPCs) self-renew and differentiate into nephrons, the functional
units of the kidney. Here, manipulation of p38 and YAP activity allowed for long-term clonal …

Kidney disease is a devastating condition affecting millions of people worldwide, where over
100,000 patients in the United States alone remain waiting for a lifesaving organ transplant …

Podocytes are exquisitely fashioned kidney cells that serve an essential role in the process
of blood filtration. Congenital malformation or damage to podocytes has dire consequences …