DNA replication and replication stress response in the context of nuclear architecture

D González-Acosta, M Lopes - Chromosoma, 2024 - Springer
The DNA replication process needs to be coordinated with other DNA metabolism
transactions and must eventually extend to the full genome, regardless of chromatin status …

Nuclear actin polymerization rapidly mediates replication fork remodeling upon stress by limiting PrimPol activity

MD Palumbieri, C Merigliano… - Nature …, 2023 - nature.com
Cells rapidly respond to replication stress actively slowing fork progression and inducing
fork reversal. How replication fork plasticity is achieved in the context of nuclear organization …

Nuclear actin dynamics and functions at a glance

S Ulferts, M Lopes, K Miyamoto… - Journal of cell …, 2024 - journals.biologists.com
Actin is well known for its cytoskeletal functions, where it helps to control and maintain cell
shape and architecture, as well as regulating cell migration and intracellular cargo transport …

MolPhase, an advanced prediction algorithm for protein phase separation

Q Liang, N Peng, Y Xie, N Kumar, W Gao… - The EMBO …, 2024 - embopress.org
We introduce MolPhase, an advanced algorithm for predicting protein phase separation
(PS) behavior that improves accuracy and reliability by utilizing diverse physicochemical …

[HTML][HTML] Chromatin plasticity in mechanotransduction

M Vivo, V Rosti, S Cervone, C Lanzuolo - Current Opinion in Cell Biology, 2024 - Elsevier
Living organisms can detect and respond to physical forces at the cellular level. The
pathways that transmit these forces to the nucleus allow cells to react quickly and …

Transmembrane formins as active cargoes of membrane trafficking

F Cvrčková, R Ghosh, H Kočová - Journal of Experimental …, 2024 - academic.oup.com
Formins are a large, evolutionarily old family of cytoskeletal regulators whose roles include
actin capping and nucleation, as well as modulation of microtubule dynamics. The plant …

Actin associates with actively elongating genes and binds directly to the Cdk9 subunit of P-TEFb

S Kyheröinen, B Prajapati, M Sokolova… - Journal of Biological …, 2024 - ASBMB
Nuclear actin has been demonstrated to be essential for optimal transcription, but the
molecular mechanisms and direct binding partner for actin in the RNA polymerase complex …

FOXL2 regulates RhoA expression to change actin cytoskeleton rearrangement in granulosa cells of chicken pre-ovulatory follicles

X Li, H Du, H Zhou, Y Huang, S Tang, C Yu… - Biology of …, 2024 - academic.oup.com
Abstract Forkhead box L2 (FOXL2) is an indispensable key regulator of female follicular
development, and it plays important roles in the morphogenesis, proliferation, and …

Purine-Rich Element Binding Protein Alpha, a Nuclear Matrix Protein, Has a Role in Prostate Cancer Progression

T Inoue, X Bao, T Kageyama, Y Sugino… - International Journal of …, 2024 - mdpi.com
Solid tumors as well as leukemias and lymphomas show striking changes in nuclear
structure including nuclear size and shape, the number and size of nucleoli, and chromatin …

Synergetic surface enhancement of quantum dots-based electrochemiluminescence with photonic crystal light scattering and metal surface plasmon resonance for …

H Lu, J Zhu, J Chen, T Tao, Y Shen, H Zhou - Talanta, 2024 - Elsevier
Noble metal nanostructures and photonic crystals (PhCs) have been widely investigated as
substrates for constructing surface enhanced electrochemiluminescence (SE-ECL) …