Apoptosis or programmed cell death is a key regulator of physiological growth control and
regulation of tissue homeostasis. One of the most important advances in cancer research in …

Defects in apoptosis underpin both tumorigenesis and drug resistance, and because of
these defects chemotherapy often fails. Understanding the molecular events that contribute …

First isolated in the early 1960s, doxorubicin (DOX) remains among the most effective
anticancer drug ever developed. However, this drug has proven to be a double-edged …

Tumor necrosis factor-related apoptosis-inducing ligand or Apo 2 ligand (TRAIL/Apo2L) is a
member of the tumor necrosis factor (TNF) family of ligands capable of initiating apoptosis …

Melanoma is the most aggressive form of skin cancer and is notoriously resistant to all
current modalities of cancer therapy. A large set of genetic, functional and biochemical …

Anticancer treatment using cytotoxic drugs is considered to mediate cell death by activating
key elements of the apoptosis program and the cellular stress response. While proteolytic …

Photodynamic therapy (PDT) has been described as a promising new modality for the
treatment of cancer. PDT involves the combination of a photosensitizing agent …

A major concern in cancer therapy is resistance of tumors such as glioblastoma to current
treatment protocols. Here, we report that transfer of the gene encoding second mitochondria …

Activation of apoptosis pathways is a key mechanism by which cytotoxic drugs kill tumor
cells. Also immunotherapy of tumors requires an apoptosis sensitive phenotype of target …

Apoptosis, the cell's intrinsic death program, is a key regulator of tissue homeostasis. An
imbalance between cell death and proliferation may result in tumor formation. Also, killing of …