The nearly 600 proteases in the human genome regulate a diversity of biological processes,
including programmed cell death. Comprehensive characterization of protease signaling in …

In this review, we discuss the role of nitric oxide synthase in doxorubicin (DOX)-induced
cardiomyopathy, a prominent side effect of DOX chemotherapy in cancer patients. It is …

Genotoxic DNA damaging agents may activate both membrane death receptors and the
endogenous mitochondrial damage pathway leading to cell death via apoptosis. Here …

Background—Sildenafil, a phosphodiesterase-5 inhibitor, induces cardioprotection against
ischemia/reperfusion injury via opening of mitochondrial KATP channels. It is unclear …

Apoptosis is a tightly regulated cell suicide program that plays an essential role in the
maintenance of tissue homeostasis by eliminating unnecessary or harmful cells. Defects in …

Annexin V and propidium iodide staining is widely used for determining the cellular death
through apoptosis. In the presence of Ca 2+ ions, annexin V has a strong binding affinity for …

We have shown previously that the death receptor CD95 could contribute to anticancer drug-
induced apoptosis of colon cancer cells. In addition, anticancer drugs cooperate with CD95 …

Acute pancreatitis is a disease of variable severity in which some patients experience mild,
self-limited attacks, whereas others manifest a severe, highly morbid, and frequently lethal …

Apoptosis is the cell's intrinsic program to death, which plays an important role in physiologic
growth control and homeostasis. Apoptosis can be triggered by death receptors (DRs) …

Apoptosis is an important phenomenon in cytotoxicity induced by anticancer drugs. Here, we
review the current status of the molecular mechanisms of anticancer drug-induced apoptosis …