As the second dimension to the genome, the epigenome contains key information specific to
every type of cells. Thousands of human epigenome maps have been produced in recent …

Malignancies are characterized by extensive global reprogramming of epigenetic patterns,
including gains or losses in DNA methylation and changes to histone marks. Furthermore …

Dynamic three-dimensional chromatin conformation is a critical mechanism for gene
regulation during development and disease. Despite this, profiling of three-dimensional …

Gene expression during development and differentiation is regulated in a cell-and stage-
specific manner by complex networks of intergenic and intragenic cis-regulatory elements …

Studies of gene rearrangements and the consequent oncogenic fusion proteins have laid
the foundation for targeted cancer therapy. To identify oncogenic fusions associated with …

Epigenetic mechanisms are proposed as an important way in which the genome responds
to the environment. Epigenetic marks, including DNA methylation and Histone modifications …

Gene enhancer elements are noncoding segments of DNA that play a central role in
regulating transcriptional programs that control development, cell identity, and evolutionary …

It is now well accepted that cell-type specific gene regulation is under the purview of
enhancers. Great strides have been made recently to characterize and identify enhancers …

All life forms sense and respond to mechanical stimuli. Throughout evolution, organisms
develop diverse mechanosensing and mechanotransduction pathways, leading to fast and …

Combined with TCR stimuli, extracellular cytokine signals initiate the differentiation of naive
CD 4+ T cells into specialized effector T‐helper (Th) and regulatory T (Treg) cell subsets …