Alzheimer's disease and related dementias (ADRD) are among the top contributors to
disability and mortality in later life. As with many chronic conditions, aging is the single most …

Microglia are central players in brain innate immunity and have been the subject of
extensive research in Alzheimer's disease (AD). In this review, we aim to summarize the …

For over a century, the importance of lipid metabolism in biology was recognized but difficult
to mechanistically understand due to the lack of sensitive and robust technologies for …

Abstract The mRNA SARS-CoV-2 vaccines were brought to market in response to the public
health crises of Covid-19. The utilization of mRNA vaccines in the context of infectious …

Background Abnormal lipid accumulation has been recognized as a key element of immune
dysregulation in microglia whose dysfunction contributes to neurodegenerative diseases …

Postoperative cognitive dysfunction (POCD) is a severe neurological complication after
anesthesia and surgery. However, there is still a lack of effective clinical pharmacotherapy …

This literature review investigates the significant overlap between myelin-repair signaling
pathways and pathways known to contribute to hallmark pathologies of Alzheimer's disease …

Abstract Oligodendrocytes (OLs), the myelin-generating cells of the central nervous system
(CNS), are active players in shaping neuronal circuitry and function. It has become …

Sphingolipids containing acyl residues that are hydroxylated at C-2 are found in most, if not
all, eukaryotes and certain bacteria. 2-hydroxylated sphingolipids are present in many …

Background Parkinson's disease (PD) is a neurodegenerative condition characterized by
the progressive loss of dopaminergic neurons within the substantia nigra …