Malaria—a parasite vector-borne disease—is a global health problem, and Plasmodium
falciparum has proven to be the deadliest among Plasmodium spp., which causes malaria in …

Background New approaches for the prevention and elimination of malaria, a leading cause
of illness and death among infants and young children globally, are needed. Methods We …

Antibodies are considered as an excellent foundation to neutralize pathogens and as highly
specific therapeutic agents. Antibodies are generated in response to a vaccine but little use …

Immunological memory is required for protection against repeated infections and is the basis
of all effective vaccines. Antibodies produced by memory B cells play an essential role in …

Discovering potent human monoclonal antibodies (mAbs) targeting the Plasmodium
falciparum circumsporozoite protein (PfCSP) on sporozoites (SPZ) and elucidating their …

Malaria transmission-blocking vaccines (TBVs) aim to elicit human antibodies that inhibit
sporogonic development of Plasmodium falciparum in mosquitoes, thereby preventing …

The generation of high-quality antibody responses to Plasmodium falciparum (Pf)
circumsporozoite protein (PfCSP), the primary surface antigen of Pf sporozoites, is …

Abstract Immunization with Plasmodium falciparum (Pf) sporozoites under
chemoprophylaxis (PfSPZ-CVac) is the most efficacious approach to malaria vaccination …

The circumsporozoite protein of the human malaria parasite Plasmodium falciparum
(PfCSP) is the main target of antibodies that prevent the infection and disease, as shown in …

Progression in computational research has made it possible for the in silico methods to offer
epochal benefits to both regulatory needs and the pharmaceutical industry to assess the …