Therapeutic applications of extracellular vesicles: clinical promise and open questions

B György, ME Hung, XO Breakefield… - Annual review of …, 2015 - annualreviews.org
This review provides an updated perspective on rapidly proliferating efforts to harness
extracellular vesicles (EVs) for therapeutic applications. We summarize current knowledge …

Exosome as a novel shuttle for delivery of therapeutics across biological barriers

CK Das, BC Jena, I Banerjee, S Das… - Molecular …, 2018 - ACS Publications
The effective delivery of target-specific siRNA to the brain by exploiting the exosomes
derived from dendritic cells renders the paradigm shift for the prospective use of nanosized …

Extracellular vesicles: techniques and biomedical applications related to single vesicle analysis

J Zhang, J Wu, G Wang, L He, Z Zheng, M Wu… - ACS …, 2023 - ACS Publications
Extracellular vesicles (EVs) are extensively dispersed lipid bilayer membrane vesicles
involved in the delivery and transportation of molecular payloads to certain cell types to …

[HTML][HTML] Biological activities of extracellular vesicles and their cargos from bovine and human milk in humans and implications for infants

J Zempleni, A Aguilar-Lozano, M Sadri, S Sukreet… - The Journal of …, 2017 - Elsevier
Extracellular vesicles (EVs) in milk harbor a variety of compounds, including lipids, proteins,
noncoding RNAs, and mRNAs. Among the various classes of EVs, exosomes are of …

The exosome‐A naturally secreted nanoparticle and its application to wound healing

S Rani, T Ritter - Advanced materials, 2016 - Wiley Online Library
Wound healing is a complex process and often delayed in patients with underlying chronic
conditions. The cost of wound care is a significant burden to the society, warranting new …

Free and hydrogel encapsulated exosome-based therapies in regenerative medicine

A Akbari, N Jabbari, R Sharifi, M Ahmadi, A Vahhabi… - Life sciences, 2020 - Elsevier
Over the last few decades, mesenchymal stem cells-derived exosomes (MSCs-Ex) have
attracted a lot of attention as a therapeutic tool in regenerative medicine. Exosomes are …

Regulatory T cell-derived extracellular vesicles modify dendritic cell function

SL Tung, DA Boardman, M Sen, M Letizia, Q Peng… - Scientific Reports, 2018 - nature.com
Regulatory T cells (Treg) are a subpopulation of T cells that maintain tolerance to self and
limit other immune responses. They achieve this through different mechanisms including the …

MicroRNAs in B-cell lymphomas: how a complex biology gets more complex

K Musilová, M Mráz - Leukemia, 2015 - nature.com
MicroRNAs (miRNAs) represent important regulators of gene expression besides
transcriptional control. miRNA regulation can be involved in the cell developmental fate …

[HTML][HTML] RNA nanotechnology-mediated cancer immunotherapy

YX Lin, Y Wang, S Blake, M Yu, L Mei, H Wang… - Theranostics, 2020 - ncbi.nlm.nih.gov
RNA molecules (eg, siRNA, microRNA, and mRNA) have shown tremendous potential for
immunomodulation and cancer immunotherapy. They can activate both innate and adaptive …

Exosomes: promising delivery tools for overcoming blood-brain barrier and glioblastoma therapy

SH Khatami, N Karami, M Taheri-Anganeh… - Molecular …, 2023 - Springer
Gliomas make up virtually 80% of all lethal primary brain tumors and are categorized based
on their cell of origin. Glioblastoma is an astrocytic tumor that has an inferior prognosis …