Signaling pathways in macrophages: molecular mechanisms and therapeutic targets

M Li, M Wang, Y Wen, H Zhang, GN Zhao, Q Gao - MedComm, 2023 - Wiley Online Library
Macrophages play diverse roles in development, homeostasis, and immunity. Accordingly,
the dysfunction of macrophages is involved in the occurrence and progression of various …

[HTML][HTML] The role of peroxisome proliferator-activated receptors in the modulation of hyperinflammation induced by SARS-CoV-2 infection: A perspective for COVID-19 …

A Hasankhani, A Bahrami, B Tavakoli-Far… - Frontiers in …, 2023 - frontiersin.org
Coronavirus disease 2019 (COVID-19) is a severe respiratory disease caused by infection
with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that affects the lower …

[HTML][HTML] Role of the Renin-Angiotensin System in long COVID's cardiovascular injuries

E Cojocaru, C Cojocaru, CE Vlad, L Eva - Biomedicines, 2023 - mdpi.com
The renin-angiotensin system (RAS) is one of the biggest challenges of cardiovascular
medicine. The significance of the RAS in the chronic progression of SARS-CoV-2 infection …

In silico identification of potential miRNAs-mRNA inflammatory networks implicated in the pathogenesis of COVID-19

SH Sheikhshabani, Z Amini-Farsani, P Modarres… - Human Gene, 2023 - Elsevier
COVID-19 has been found to affect the expression profile of several mRNAs and miRNAs,
leading to dysregulation of a number of signaling pathways, particularly those related to …

[HTML][HTML] A retrospective study of Pupingqinghua prescription versus Lianhuaqingwen in Chinese participants infected with SARS-CoV-2 Omicron variants

Y Dong, W Zhai, B Fang, C Liu, S Yuan… - Frontiers in …, 2022 - frontiersin.org
Background: Coronavirus disease (COVID-19) seriously endangers global public health.
Pupingqinghua prescription (PPQH) is an herbal formula from traditional Chinese medicine …

[HTML][HTML] Diagnostic, prognostic and mechanistic biomarkers of COVID-19 Identified by mass spectrometric metabolomics

M Bourgin, S Durand, G Kroemer - Metabolites, 2023 - mdpi.com
A number of studies have assessed the impact of SARS-CoV-2 infection and COVID-19
severity on the metabolome of exhaled air, saliva, plasma, and urine to identify diagnostic …

Immune cell-derived extracellular vesicles for precision therapy of inflammatory-related diseases

S Li, W Li, X Wu, B Zhang, L Liu, L Yin - Journal of Controlled Release, 2024 - Elsevier
Inflammation-related diseases impose a significant global health burden, necessitating
urgent exploration of novel treatment modalities for improved clinical outcomes. We begin by …

[HTML][HTML] Cytokine levels and severity of illness scoring systems to predict mortality in COVID-19 infection

S Onuk, H Sipahioğlu, S Karahan, A Yeşiltepe… - Healthcare, 2023 - mdpi.com
Various scoring systems and cytokines have been cited as predicting disease severity in
COVID-19 infection. This study analyzed the link between mortality rate, levels of cytokines …

[HTML][HTML] Role of sphingosine 1-phosphate (S1P) in sepsis-associated intestinal injury

G Sun, B Wang, H Zhu, J Ye, X Liu - Frontiers in Medicine, 2023 - ncbi.nlm.nih.gov
Abstract Sphingosine-1-phosphate (S1P) is a widespread lipid signaling molecule that binds
to five sphingosine-1-phosphate receptors (S1PRs) to regulate downstream signaling …

Inhibitory effect of food-functioned phytochemicals on dysregulated inflammatory pathways triggered by SARS-CoV-2: a mechanistic review

I Jantan, NA Norahmad, Yuandani… - Critical Reviews in …, 2024 - Taylor & Francis
Inflammatory cascades of the dysregulated inflammatory pathways in COVID-19 can cause
excessive production of pro-inflammatory cytokines and chemokines leading to cytokine …