Preclinical models for drug discovery for metastatic disease

L Wakefield, S Agarwal, K Tanner - Cell, 2023 - cell.com
Despite many advances, metastatic disease remains essentially uncurable. Thus, there is an
urgent need to better understand mechanisms that promote metastasis, drive tumor …

Application of Zebrafish as a Model for Anti-Cancer Activity Evaluation and Toxicity Testing of Natural Products

Y Shen, R Sheng, R Guo - Pharmaceuticals, 2023 - mdpi.com
Developing natural product-based anti-cancer drugs/agents is a promising way to overcome
the serious side effects and toxicity of traditional chemotherapeutics for cancer treatment …

Neurotoxicity of the Cu(OH)2 Nanopesticide through Perturbing Multiple Neurotransmitter Pathways in Developing Zebrafish

S Chen, Y Qin, X Ye, J Liu, X Yan, L Zhou… - Environmental …, 2023 - ACS Publications
The copper hydroxide [Cu (OH) 2] nanopesticide is an emerging agricultural chemical that
can negatively impact aquatic organisms. This study evaluated the behavioral changes of …

Facial analytics based on a coordinate extrapolation system (zFACE) for morphometric phenotyping of developing zebrafish

L Maili, OE Ruiz, PH Kahan, F Chiu… - Disease Models & …, 2023 - journals.biologists.com
Facial development requires a complex and coordinated series of cellular events that, when
perturbed, can lead to structural birth defects. A quantitative approach to quickly assess …

Imaging Approaches to Investigate Pathophysiological Mechanisms of Brain Disease in Zebrafish

L Turrini, L Roschi, G de Vito, FS Pavone… - International Journal of …, 2023 - mdpi.com
Zebrafish has become an essential model organism in modern biomedical research. Owing
to its distinctive features and high grade of genomic homology with humans, it is increasingly …

Animal models of silicosis: fishing for new therapeutic targets and treatments

A Martínez-López, S Candel… - European Respiratory …, 2023 - Eur Respiratory Soc
Silicosis as an occupational lung disease has been present in our lives for centuries.
Research studies have already developed and implemented many animal models to study …

Author Spotlight: High-Resolution 4D Light-Sheet Imaging and Virtual Reality in Zebrafish for Single-Cell Analysis of Heart Function

X Zhang, A Saberigarakani, M Almasian… - JoVE (Journal of …, 2024 - jove.com
Zebrafish is an intriguing model organism known for its remarkable cardiac regeneration
capacity. Studying the contracting heart in vivo is essential for gaining insights into structural …

Three-dimensional cerebral vasculature topological parameter extraction of transgenic zebrafish embryos with a filling-enhancement deep learning network

C Chen, YJ Tang, Y Tan, LB Wang, H Li - Biomedical Optics Express, 2023 - opg.optica.org
Quantitative analysis of zebrafish cerebral vasculature is essential for the study of vascular
development and disease. We developed a method to accurately extract the cerebral …

Evidence for Adverse Effects on Liver Development and Regeneration in Zebrafish by Decabromodiphenyl Ethane

F Li, G Song, X Wang, Y Sun, S Zhou… - Environmental …, 2023 - ACS Publications
Decabromodiphenyl ethane (DBDPE), a ubiquitous emerging pollutant, could be enriched in
the liver of organisms, but its effects and mechanisms on liver development and …

Ipconazole disrupts mitochondrial homeostasis and alters GABAergic neuronal development in zebrafish

G Lee, A Banik, J Eum, BJ Hwang, SH Kwon… - International Journal of …, 2022 - mdpi.com
Ipconazole, a demethylation inhibitor of fungal ergosterol biosynthesis, is widely used in
modern agriculture for foliar and seed treatment, and is authorized for use in livestock feed …