COVID-19 heart lesions in children: Clinical, diagnostic and immunological changes

E Vasichkina, D Alekseeva, I Kudryavtsev… - International Journal of …, 2023 - mdpi.com
In the beginning of COVID-19, the proportion of confirmed cases in the pediatric population
was relatively small and there was an opinion that children often had a mild or asymptomatic …

Roles of host proteases in the entry of SARS-CoV-2

A Zabiegala, Y Kim, KO Chang - Animal Diseases, 2023 - Springer
The spike protein (S) of SARS-CoV-2 is responsible for viral attachment and entry, thus a
major factor for host susceptibility, tissue tropism, virulence and pathogenicity. The S is …

[HTML][HTML] Relationship between endothelial and angiogenesis biomarkers envisage mortality in a prospective cohort of COVID-19 patients requiring respiratory support

F Maldonado, D Morales, C Díaz-Papapietro… - Frontiers in …, 2022 - frontiersin.org
Purpose Endothelial damage and angiogenesis are fundamental elements of
neovascularisation and fibrosis observed in patients with coronavirus disease 2019 (COVID …

Possible role of matrix metalloproteinases and TGF-β in COVID-19 severity and sequelae

G Ramírez-Martínez, LA Jiménez-Álvarez… - Journal of interferon & …, 2022 - liebertpub.com
The costs of coronavirus disease 2019 (COVID-19) are devastating. With millions of deaths
worldwide, specific serological biomarkers, antiviral agents, and novel therapies are …

Molecular and immune signatures, and pathological trajectories of fatal COVID‐19 lungs defined by in situ spatial single‐cell transcriptome analysis

A Das, W Meng, Z Liu, MM Hasib… - Journal of Medical …, 2023 - Wiley Online Library
Despite intensive studies during the last 3 years, the pathology and underlying molecular
mechanism of coronavirus disease 2019 (COVID‐19) remain poorly defined. In this study …

Long COVID: a narrative review of the clinical aftermaths of COVID-19 with a focus on the putative pathophysiology and aspects of physical activity

S Haunhorst, W Bloch, H Wagner, C Ellert… - Oxford Open …, 2022 - academic.oup.com
The pandemic coronavirus disease 2019 (COVID-19) can cause multi-systemic symptoms
that can persist beyond the acute symptomatic phase. The post-acute sequelae of COVID-19 …

S protein, ACE2 and host cell proteases in SARS-CoV-2 cell entry and infectivity; is soluble ACE2 a two blade sword? A narrative review

R Nejat, MF Torshizi, DJ Najafi - Vaccines, 2023 - mdpi.com
Since the spread of the deadly virus SARS-CoV-2 in late 2019, researchers have restlessly
sought to unravel how the virus enters the host cells. Some proteins on each side of the …

COVID-19 and fibrosis: Mechanisms, clinical relevance, and future perspectives

MA Saifi, S Bansod, C Godugu - Drug Discovery Today, 2022 - Elsevier
Highlights•The development of fibrosis in COVID-19 survivors is a major concern.•Although,
the fibrosis is resolved over time, there is a concern of residual effects of viral infection in the …

Longitudinal plasma proteomic analysis of 1117 hospitalized patients with COVID-19 identifies features associated with severity and outcomes

A Viode, KK Smolen, P van Zalm, D Stevenson… - Science …, 2024 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is characterized
by highly heterogeneous manifestations ranging from asymptomatic cases to death for still …

Long COVID-19 Pathophysiology: What Do We Know So Far?

NR Tziolos, P Ioannou, S Baliou, DP Kofteridis - Microorganisms, 2023 - mdpi.com
Long COVID-19 is a recognized entity that affects millions of people worldwide. Its broad
clinical symptoms include thrombotic events, brain fog, myocarditis, shortness of breath …