Two founder variants account for over 90% of pathogenic BRCA alleles in Orkney and Shetland

SM Kerr, L Klaric, MD Muckian, E Cowan, L Snadden… - medRxiv, 2024 - medrxiv.org
For breast and ovarian cancer risk assessment in the isolated populations of the Northern
Isles of Orkney and Shetland (in Scotland, UK) and their diasporas, quantifying genetically …

[HTML][HTML] Associations of plasma omega-6 and omega-3 fatty acids with overall and 19 site-specific cancers: a population-based cohort study in UK Biobank

Y Zhang, Y Sun, S Song, NK Khankari, JT Brenna… - medRxiv, 2024 - ncbi.nlm.nih.gov
Background Previous epidemiological studies of the associations between polyunsaturated
fatty acids (PUFAs) and cancer incidence have been inconsistent. We investigated the …

Association of daily steps with incident non-alcoholic fatty liver disease: Evidence from the UK Biobank cohort

ES Fulda, L Portas, C Harper, D Preiss, D Bennett… - medRxiv, 2024 - medrxiv.org
Background: Low physical activity (PA) has been shown to be associated with higher risk of
non-alcoholic fatty liver disease (NAFLD). However, the strength and shape of this …

Respiratory viral infection promotes the awakening and outgrowth of dormant metastatic breast cancer cells in lungs

SB Chia, BJ Johnson, J Hu, R Vermeulen… - Research …, 2024 - researchsquare.com
Breast cancer is the second most common cancer globally. Most deaths from breast cancer
are due to metastatic disease which often follows long periods of clinical dormancy 1 …

Efficient storage and regression computation for population-scale genome sequencing studies

MA Rivas, C Chang - bioRxiv, 2024 - biorxiv.org
In the era of big data in human genetics, large-scale biobanks aggregating genetic data from
diverse populations have emerged as important for advancing our understanding of human …