According to the Geroscience concept that organismal aging and age-associated diseases
share the same basic molecular mechanisms, the identification of biomarkers of age that can …

The discovery of a pathogenic variant in the alpha-synuclein (SNCA) gene in the Contursi
kindred in 1997 indisputably confirmed a genetic cause in a subset of Parkinson's disease …

Background There is evidence that complex diseases and mortality are associated with DNA
methylation (DNAm) and age acceleration. Numerous epigenetic clocks, including Horvath …

Background Biological ageing is one of the principal risk factors for neurodegenerative
diseases. It is becoming increasingly clear that acceleration of DNA methylation age, as …

Rapid eye movement sleep behavior disorder (RBD) is the strongest prodromal marker for α‐
synucleinopathies. The Horvath DNA methylation age (DNAm‐age) is an epigenetic clock …

Background Aging is a significant risk factor for many neurodegenerative diseases and
neurological tumors. Previous studies indicate that the frailty index, facial aging, telomere …

Parkinson's disease (PD) presents one of the most common neurodegenerative movement
disorders with a clinically heterogeneous phenotype and ambiguous pathological …

Background Aging has always been considered as a risk factor for neurodegenerative
diseases, but there are individual differences and its mechanism is not yet clear. Epigenetics …

Health problems associated with aging are a major public health concern for the future.
Aging is a complex process with wide intervariability among individuals. Therefore, there is a …

Background Aging clocks tag the actual underlying age of an organism and its discrepancy
with chronological age and have been reported to predict incident disease risk in the …