Targeting the NLRP3 inflammasome in cardiovascular diseases

S Toldo, E Mezzaroma, LF Buckley, N Potere… - Pharmacology & …, 2022 - Elsevier
The NACHT, leucine-rich repeat (LRR), and pyrin domain (PYD)-containing protein 3
(NLRP3) inflammasome is an intracellular sensing protein complex that plays a major role in …

[HTML][HTML] Interleukin-1 and the NLRP3 inflammasome in COVID-19: Pathogenetic and therapeutic implications

N Potere, MG Del Buono, R Caricchio, PC Cremer… - …, 2022 - thelancet.com
A hyperinflammatory response during severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection crucially worsens clinical evolution of coronavirus disease 2019 …

SARS-CoV-2 spike S1 subunit induces neuroinflammatory, microglial and behavioral sickness responses: Evidence of PAMP-like properties

MG Frank, KH Nguyen, JB Ball, S Hopkins… - Brain, Behavior, and …, 2022 - Elsevier
SARS-CoV-2 infection produces neuroinflammation as well as neurological, cognitive (ie,
brain fog), and neuropsychiatric symptoms (eg, depression, anxiety), which can persist for …

Inflammation at the crossroads of COVID-19, cognitive deficits and depression

NML e Silva, FGQ Barros-Aragão, FG De Felice… - …, 2022 - Elsevier
Acute neurological alterations have been associated with SARS-CoV-2 infection.
Additionally, it is becoming clear that coronavirus disease 2019 (COVID-19) survivors may …

[HTML][HTML] SARS-CoV-2 spike glycoprotein S1 induces neuroinflammation in BV-2 microglia

OA Olajide, VU Iwuanyanwu, OD Adegbola… - Molecular …, 2022 - Springer
In addition to respiratory complications produced by SARS‐CoV‐2, accumulating evidence
suggests that some neurological symptoms are associated with the disease caused by this …

[HTML][HTML] The SARS-CoV-2 S1 spike protein promotes MAPK and NF-kB activation in human lung cells and inflammatory cytokine production in human lung and …

CB Forsyth, L Zhang, A Bhushan, B Swanson, L Zhang… - Microorganisms, 2022 - mdpi.com
The coronavirus disease 2019 (COVID-19) pandemic began in January 2020 in Wuhan,
China, with a new coronavirus designated SARS-CoV-2. The principal cause of death from …

[HTML][HTML] Cyanidin-3-O-glucoside and peonidin-3-O-glucoside-rich fraction of black rice germ and bran suppresses inflammatory responses from SARS-CoV-2 spike …

W Semmarath, S Mapoung, S Umsumarng, P Arjsri… - Nutrients, 2022 - mdpi.com
Black rice is a functional food that is high in anthocyanin content, primarily C3G and P3G. It
possesses nutraceutical properties that exhibit a range of beneficial effects on human …

Exploring the immunogenic properties of SARS-CoV-2 structural proteins: PAMP: TLR signaling in the mediation of the neuroinflammatory and neurologic sequelae of …

MG Frank, M Fleshner, SF Maier - Brain, Behavior, and Immunity, 2023 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) produces an array of
neurologic and neuropsychiatric symptoms in the acute and post-acute phase of infection …

[HTML][HTML] NLRP3 inflammasome activation and SARS-CoV-2-mediated hyperinflammation, cytokine storm and neurological syndromes

D Dutta, J Liu, H Xiong - International journal of physiology …, 2022 - ncbi.nlm.nih.gov
Despite the introduction of vaccines and drugs for SARS-CoV-2, the COVID-19 pandemic
continues to spread throughout the world. In severe COVID-19 patients, elevated levels of …

[HTML][HTML] Potential benefits of ginseng against COVID-19 by targeting inflammasomes

YS Yi - Journal of Ginseng Research, 2022 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogenic virus that
causes coronavirus disease 2019 (COVID-19), with major symptoms including hyper …