Cholesterol homeostasis is essential in normal physiology of all cells. One of several
proteins involved in cholesterol homeostasis is the ATP-binding cassette transporter A1 …

Background The retina, as part of the central nervous system (CNS) with limited capacity for
self-reparation and regeneration in mammals, is under cumulative environmental stress due …

Glaucoma, a diverse group of eye disorders that results in the degeneration of retinal
ganglion cells, is the world's leading cause of irreversible blindness. Apart from age and …

Damage to the optic nerve and the death of associated retinal ganglion cells (RGCs) by
elevated intraocular pressure (IOP), also known as glaucoma, is responsible for visual …

The fatty acid composition of photoreceptor outer segment (POS) phospholipids diverges
from other membranes, being highly enriched in polyunsaturated fatty acids (PUFAs). The …

Caveolae, specialized plasma membrane invaginations present in most cell types, play
important roles in multiple cellular processes including cell signaling, lipid uptake and …

Glaucoma, a neurodegenerative disorder that leads to irreversible blindness, remains a
challenge because of its complex nature. MicroRNAs (miRNAs) are crucial regulators of …

Glaucoma is the main cause of irreversible visual loss worldwide, and comprises a group of
progressive, age-related, and chronic optic neuropathies. Prostaglandin analogs are …

Glaucoma is a neurodegenerative disease in which optic nerve damage and visual field
defects occur. It is a leading cause of irreversible blindness. Its pathogenesis is largely …

Glaucoma is one of the world's leading causes of irreversible blindness. A complex,
multifactorial disease, the underlying pathogenesis and reasons for disease progression are …