Candidate cis-regulatory elements (cCREs) in microglia demonstrate the most substantial
enrichment for Alzheimer's disease (AD) heritability compared to other brain cell types …

Cholesterol homeostasis is impaired in Alzheimer's disease; however, attempts to modulate
brain cholesterol biology have not translated into tangible clinical benefits for patients to …

Microglia and neuroinflammation play an important role in the development and progression
of Alzheimer's disease (AD). Inositol polyphosphate-5-phosphatase D (INPP5D/SHIP1) is a …

Microglia are tissue-resident macrophages and professional phagocytes of the central
nervous system (CNS). In development, microglia-mediated phagocytosis is important for …

Summary Microglia (MG), the brain-resident macrophages, play major roles in health and
disease via a diversity of cellular states. While embryonic MG display a large heterogeneity …

Microglia replacement strategies are increasingly being considered for the treatment of
primary microgliopathies like adult-onset leukoencephalopathy with axonal spheroids and …

Background Emerging evidence has shown that myeloid cells that infiltrate into the peri-
infarct region may influence the progression of ischemic stroke by interacting with microglia …

Genetic and experimental evidence suggests that Alzheimer's disease (AD) risk alleles and
genes may influence disease susceptibility by altering the transcriptional and cellular …

Microglia are usually referred to as “the innate immune cells of the brain,”“the resident
macrophages of the central nervous system”(CNS), or “CNS parenchymal macrophages.” …

Highlights•Microglia assume diverse states across developmental periods and
pathologies.•Brain environment drives selection and function of microglial …