The peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated
transcriptional factor that belongs to the nuclear hormone receptor superfamily. PPARγ was …

Abstract Parkinson's disease (PD), the most common movement disorder, comprises several
pathophysiologic mechanisms including misfolded alpha‐synuclein aggregation …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a
pandemic disease (COVID-19) that has spread globally causing more than 30,000 deaths …

Background Discoveries that microglia-mediated neuroinflammation is involved in the
pathological process of depression provided a new strategy for novel antidepressant …

Thiazolidinedione (TZD) drugs used in the treatment of type 2 diabetes mellitus (T2DM)
have proven effective in improving insulin sensitivity, hyperglycemia, and lipid metabolism …

Parkinson's disease (PD) is a common chronic progressive neurodegenerative disorder in
elderly people. A consistent neurochemical abnormality in PD is degeneration of …

Over 25 years have passed since peroxisome proliferators‐activated receptors (PPARs),
were first described. Like other members of the nuclear receptors superfamily, PPARs have …

Nuclear receptors (NRs) play central roles in metabolic syndrome, making them attractive
drug targets despite the challenge of achieving functional selectivity. For instance, members …

Thiazolidinedione (TZD) class of peroxisome proliferator receptor gamma (PPAR-γ) agonists
display neuroprotective effects in experimental Parkinson's disease (PD) models. Neurons …

Chronic neuroinflammation is associated with the pathophysiology of Parkinson's disease, a
movement disorder characterised by deterioration of the nigrostriatal system of the brain …